Controllable release from magnetoliposomes by magnetic stimulation and thermal stimulation
Controllable release from magnetoliposomes by magnetic stimulation and thermal stimulation
复制标题
通过磁刺激和热刺激从磁脂质体中可控释放
DOI：
10.1016/j.colsurfb.2012.11.033
复制
发表时间：
2013-04-01
影响因子：
5.8
通讯作者：
An, Xueqin
中科院分区：
文献类型：
--
作者：
Qiu, Dan;An, Xueqin
采用超临界二氧化碳（scCO（2））法制备了包埋超顺磁性氧化铁纳米粒的脂质体。脂质体在温度和交变电磁场的共同作用下可以释放出药物。从荧光探针法研究微结构变化的角度解释了其释放机理。通过开关AMF，可以控制脂质体的内容物重复释放。结果表明，脂质体的释放是由于磁热效应引起的脂质体相变和磁推动运动导致双层通透性的提高，而不是脂质体结构的破坏。(c)2012爱思唯尔有限公司版权所有。
Liposomes with superparamagnetic iron oxide nanoparticles embedded in membrane were prepared by the supercritical carbon dioxide (scCO(2)) method. The cargos can be released from liposomes by both triggered agents, temperature and alternating current electromagnetic field (AMF). The release mechanism was explained from the view of microstructure change investigated by fluorescence probe method. The contents could be repetitively released from liposomes controlled by switching on and off the AMF. The results indicated that the release from the liposomes was due to the magnetocaloric effect resulting in the liposome phase transition and the magnetic-impelled motions leading to the improved bilayer permeability, rather than the destruction of the liposome structure. (c) 2012 Elsevier B.V. All rights reserved.