Formation and maintenance of the BBB
Formation and maintenance of the BBB
复制标题
DOI：
10.1016/j.mod.2015.07.007
复制
发表时间：
2015-11-01
影响因子：
2.6
通讯作者：
Daneman, Richard
中科院分区：
文献类型：
--
作者：
Blanchette, Marie;Daneman, Richard
中枢神经系统（CNS）由密集的毛细血管网络血管化，所述毛细血管网络对于从神经组织递送氧气和营养物以及去除二氧化碳和废物是至关重要的。这些血管包含一系列特性，称为血脑屏障（BBB），这将它们与其他组织中的脉管系统区分开来，使CNS血管能够严格调节血液和组织之间的离子，分子和细胞的转移。该屏障对于维持脑稳态是至关重要的，其允许适当的神经元功能并且还保护组织免受损伤和疾病，并且许多神经系统疾病与BBB功能障碍相关，包括创伤性脑损伤、阿尔茨海默病、中风、癫痫和多发性硬化。因此，更好地了解控制BBB发展的机制可能会导致对这些疾病的病理生理学的更好理解，并进一步帮助识别调节屏障以治疗不同神经系统疾病的靶点。BBB的许多特性由形成血管壁的内皮细胞所拥有，但在其发育过程中通过与微环境的一系列复杂的细胞相互作用而获得。我们将回顾什么是已知的诱导和调节血脑屏障的属性在发展过程中。(C)2015爱思唯尔爱尔兰有限公司版权所有。
The central nervous system (CNS) is vascularized by a dense capillary network that is critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from the neural tissue. These blood vessels contain a series of properties, termed the blood-brain barrier (BBB), which distinguishes them from vasculature in other tissues, enabling CNS vessels to stringently regulate the transfer of ions, molecules and cells between the blood and the tissue. This barrier is critical to maintain brain homeostasis which allows for proper neuronal function and also to protect the tissue from injury and disease and many neurological diseases are associated with BBB dysfunction, including traumatic brain injuries, Alzheimer's disease, stroke, epilepsy, and multiple sclerosis. Therefore, a better understanding of the mechanisms controlling the development of the BBB may lead to improved comprehension of the pathophysiology of these diseases, and further aid in the identification of targets to modulate the barrier to treat different neurological diseases. Many of the properties of the BBB are possessed by the endothelial cells that form the walls of the blood vessels but are acquired through a series of complex cellular interactions with the microenvironment throughout its development. We will review what is known about the induction and regulation of BBB properties during development. (C) 2015 Elsevier Ireland Ltd. All rights reserved.