Post-ablative serum thyroglobulin is an independent predictor of recurrence in low-risk differentiated thyroid carcinoma: a 16-year follow-up study
Post-ablative serum thyroglobulin is an independent predictor of recurrence in low-risk differentiated thyroid carcinoma: a 16-year follow-up study
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DOI：
10.1530/eje-10-0553
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发表时间：
2010-11-01
影响因子：
5.8
通讯作者：
Schalin-Jantti, Camilla
中科院分区：
文献类型：
--
作者：
Pelttari, Hanna;Valimaki, Matti J.;Schalin-Jantti, Camilla
目的：研究手术后和/或消融后甲状腺球蛋白 (Tg) 浓度是否可以作为 TNM I 期或 II 期高分化甲状腺癌 (WDTC) 患者疾病复发的独立预测因子。设计：一项中位随访时间为 16 年（范围 10-24）的观察性回顾性研究。患者和测量：术后和消融后 Tg 浓度、年龄、肿瘤大小、局部浸润对 495 名低风险（TNM I 期和 II 期）患者进行了初次手术时的淋巴结转移、疾病复发和癌症特异性死亡的评估，其中大多数患者接受了甲状腺全切除术和放射性碘残留消融作为初始治疗。 结果：51 名患者（10.3%）在随访期间出现疾病复发。在多元逻辑回归分析中，消融后 Tg 浓度（比值比 (OR) 3.72，置信区间 (CI) 1.71-8.05，P=0.0009）和初次手术局部浸润（OR 2.66，CI 1.03-6.90，P=0.04）是复发的唯一独立预测因子。结论：消融后 Tg 浓度是疾病复发的强有力预测因子。 WDTC。
Objective: To study whether post-surgical and/or post-ablative thyroglobulin (Tg) concentrations may serve as independent predictors of disease recurrence in patients treated for TNM stage I or II well-differentiated thyroid carcinoma (WDTC).Design: An observational retrospective study with a median follow-up of 16 years (range 10-24).Patients and measurements: Post-operative and post-ablative Tg concentrations, age, tumour size, local infiltration and nodal metastasis at primary surgery as well as disease recurrences and cancer-specific deaths were evaluated in 495 low-risk (TNM stages I and II) patients, the majority of whom had total thyroidectomy and radioactive iodine remnant ablation as initial treatment.Results: Fifty-one patients (10.3%) experienced disease recurrence during follow-up. In multiple logistic regression analysis, post-ablative Tg concentrations (odds ratio (OR) 3.72, confidence interval (CI) 1.71-8.05, P=0.0009) and local infiltration on primary surgery (OR 2.66, CI 1.03-6.90, P=0.04) were the only independent predictors of recurrence.Conclusions: Post-ablative Tg concentration is a strong predictor of disease recurrence in WDTC.