Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease
Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease
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DOI：
10.1037//0894-4105.16.3.335
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发表时间：
2002-07-01
期刊：
影响因子：
2.4
通讯作者：
Salmon, DP
中科院分区：
文献类型：
--
作者：
Bondi, MW;Serody, AB;Salmon, DP
Stroop Color-Word Test （SCWT； C. Golden, 1978）在59名可能患有阿尔茨海默病（AD）的患者和51名具有人口统计学可比性的正常对照（NC）参与者中进行了检查。AD患者的Stroop干扰效应明显大于NC参与者，痴呆严重程度显著影响SCWT的表现。主成分分析表明，在Stroop试验中，NC参与者和AD患者之间的因素结构存在分离，这表明AD患者语义知识和言语加工速度的中断可能是导致不一致试验结果受损的主要因素。尸检证实的AD亚组的临床病理相关性结果进一步表明，成功的SCWT表现背后有一个由皮质区域、执行和语言过程组成的广泛网络。
The Stroop Color-Word Test (SCWT; C. Golden, 1978) was examined in 59 patients with probable Alzheimer's disease (AD) and in 51 demographically comparable normal control (NC) participants. AD patients produced significantly larger Stroop interference effects than NC participants, and level of dementia severity significantly influenced SCWT performance. Principal-components analyses demonstrated a dissociation in the factor structure of the Stroop trials between NC participants and AD patients, suggesting that disruption of semantic knowledge and speeded verbal processing in AD may be a major contributor to impairment on the incongruent trial. Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance.