Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex
Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex
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DOI：
10.1176/appi.ajp.163.4.740
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发表时间：
2006-04-01
影响因子：
17.7
通讯作者：
Weinberger, DR
中科院分区：
文献类型：
--
作者：
Marenco, S;Steele, SU;Weinberger, DR
目的：本研究旨在证实代谢性谷氨酸受体3 （GRM3）基因（一种被认为是精神分裂症的危险因素）的单核苷酸多态性（SNP）对健康对照者n -乙酰天冬氨酸测定的影响。方法：54名精心筛选的健康志愿者，基因分型为SNP rs6465084，在3 T时进行磁共振波谱成像（MRSI）和选择的神经心理测试。结果：与G携带者相比，A/A基因型组右背外侧前额叶皮层n -乙酰天冬氨酸/肌酸水平显著降低。在左背外侧前额叶皮层和前额叶皮层附近的白质中也有相同的趋势。结论：这些发现提供了GRM3影响前额叶功能的进一步证据，并且由SNP rs6465084监测的GRM3变异影响GRM3功能。
Objective: This study was carried out to confirm prior evidence of an effect of a single nucleotide polymorphism ( SNP) in the metabotropic glutamate receptor 3 ( GRM3) gene ( a putative risk factor for schizophrenia) on measures of N-acetylaspartate in healthy comparison subjects.Method: Fifty-four carefully screened healthy volunteers genotyped at SNP rs6465084 underwent magnetic resonance spectroscopic imaging ( MRSI) at 3 T and selected neuropsychological testing.Results: The A/A genotype group exhibited a significant reduction of N-acetylaspartate/ creatine levels in the right dorsolateral prefrontal cortex compared to the G carriers. A tendency in the same direction was seen in the left dorsolateral prefrontal cortex and in the white matter adjacent to the prefrontal cortex.Conclusions: These findings provide further evidence that GRM3 affects prefrontal function and that variation in GRM3, monitored by SNP rs6465084, affects GRM3 function.