PET physiological measurements using constant infusion
PET physiological measurements using constant infusion
复制标题
DOI：
10.1016/s0969-8051(00)00138-4
复制
发表时间：
2000-10-01
影响因子：
3.1
通讯作者：
Carson, RE
中科院分区：
文献类型：
--
作者：
Carson, RE
广泛的研究设计可以与正电子发射断层扫描方法一起使用，以提供生理参数的定量测量。虽然大剂量注射示踪剂是传统的方法，但大剂量加持续输注的联合使用为受体结合示踪剂提供了许多优势。最近的兴趣是使用这种方法来动态跟踪在体内神经递质浓度变化期间示踪剂的位移。本文概述了在使用大剂量/输注方法与常规大剂量注射进行受体结合研究的权衡。核医学生物学27；7:657 - 660, 2000。(C) 2000 Elsevier Science Inc.；版权所有。
A wide range of study designs can be used with positron emission tomography methods to provide quantitative measurements of physiological parameters. While bolus injection of tracer is the conventional approach, use of combined bolus plus constant infusion provides a number of advantages fur receptor binding tracers. Of recent interest is the use of this approach to dynamically follow the displacement of tracer during in vivo changes in neurotransmitter concentrations. This paper provides an overview of the tradeoffs in using bolus/infusion methods versus conventional bolus injection for receptor binding studies. NUCL MED BIOL 27;7:657-660, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.