Bone cancer pain:: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis
Bone cancer pain:: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis
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DOI：
10.1016/j.pain.2004.06.015
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发表时间：
2004-09-01
期刊：
影响因子：
7.4
通讯作者：
Mantyh, PW
中科院分区：
文献类型：
--
作者：
Sevcik, MA;Luger, NM;Mantyh, PW
转移性乳腺癌、肺癌或前列腺癌的患者经常会有明显的骨癌疼痛。在本报告中，我们在一个活体小鼠模型中研究了双膦酸阿伦磷酸酯对骨癌疼痛、骨重塑和肿瘤生长和坏死的影响。将绿色荧光蛋白转基因小鼠溶骨肿瘤细胞注射并限制于雄性C3H/HeJ小鼠股骨骨髓间隙后，从肿瘤形成时起至骨癌疼痛加重时，长期给予阿伦磷酸钠。阿伦磷酸钠治疗减少了持续的和运动诱发的骨癌疼痛、骨骼破坏和支配骨骼的感觉神经纤维的破坏。然而，阿伦磷酸钠治疗并未改变存活的肿瘤负担，肿瘤生长和肿瘤坏死均增加。这些数据强调，使用一个可以同时评估疼痛、骨骼重塑和肿瘤生长的模型是至关重要的，因为它们中的每一个都会显著影响患者的生活质量和生存。(C)2004年国际疼痛研究协会。爱思唯尔出版，版权所有。
Patients with metastatic breast, lung or prostate cancer frequently have significant bone cancer pain. In the present report we address, in a single in vivo mouse model, the effects the bisphosphonate alendronate has on bone cancer pain, bone remodeling and tumor growth and necrosis. Following injection and confinement of green fluorescent protein-transfected murine osteolytic tumor cells into the marrow space of the femur of male C3H/HeJ mice, alendronate was administered chronically from the time the tumor was established until the bone cancer pain became severe. Alendronate therapy reduced ongoing and movement-evoked bone cancer pain, bone destruction and the destruction of sensory nerve fibers that innervate the bone. Whereas, alendronate treatment did not change viable tumor burden, both tumor growth and tumor necrosis increased. These data emphasize that it is essential to utilize a model where pain, skeletal remodeling and tumor growth can be simultaneously assessed, as each of these can significantly impact patient quality of life and survival. (C) 2004 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.