Quantitative Trait Loci and Antagonistic Associations for Two Developmentally Related Traits in the Drosophila Head.
Quantitative Trait Loci and Antagonistic Associations for Two Developmentally Related Traits in the Drosophila Head.
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果蝇头中两个与发展相关的性状的定量性状基因座和拮抗剂关联。
DOI：
10.1093/jisesa/iew115
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Gomez FH
中科院分区：
文献类型：
--
作者：
Norry FM;Gomez FH
在昆虫中，一些与发育相关的性状是负相关的。在这里，我们绘制了眼大小和头囊性状的数量性状基因座（QTL），在一组洲际重组近交系（RILs）的果蝇。复合区间作图确定了所有主要染色体上的QTL。两个负相关的性状（眼睛大小和眼间距）受到一个QTL的影响，该QTL在性状之间表现为拮抗（QTL细胞学范围为25 F5 - 30 A6），与头囊这些性状之间的负遗传相关一致。跨性状的QTL比较表明基因组上的非随机分布，跨性状的一些QTL之间存在相当大的重叠。发育相关性状受QTL影响的模式与1）性状之间的遗传相关性的标志和2）性状中的微进化分化的约束一致。
In insects, some developmentally related traits are negatively correlated. Here, we mapped Quantitative Trait Loci (QTL) for traits of eye size and head capsule, in an intercontinental set of recombinant inbred lines (RILs) of Drosophila melanogaster. Composite interval mapping identified QTL on all major chromosomes. Two negatively correlated traits (size of eyes and between-eyes distance) were influenced by one QTL that appeared to be antagonistic between the traits (QTL cytological range is 25F5–30A6), consistent with a negative genetic correlation between these traits of the head capsule. Comparisons of QTL across traits indicated a nonrandom distribution over the genome, with a considerable overlap between some QTL across traits. Developmentally-related traits were influenced by QTL in a pattern that is consistent both with 1) the sign of the genetic correlation between the traits and 2) a constraint in the micro-evolutionary differentiation in the traits.