Tissue plasminogen activator in the treatment of experimental retinal vein occlusion.
Tissue plasminogen activator in the treatment of experimental retinal vein occlusion.
复制标题
组织纤溶酶原激活剂治疗实验性视网膜静脉阻塞。
DOI：
10.1097/00006982-198909010-00001
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Khoobehi,B
中科院分区：
文献类型：
--
作者：
Oncel,M;Peyman,GA;Khoobehi,B
结肠;随机选择28只兔眼，观察重组组织型纤溶酶原激活剂（t-PA）对光化学诱导的视网膜静脉阻塞（retinal vein occlusion）的溶栓作用。组织学证实闭塞，并通过荧光素血管造影进行评估。16只眼静脉注射重组组织型纤溶酶原激活剂，12只对照眼静脉注射等量生理盐水。在治疗前和治疗后不同时间点进行血管造影。治疗后4小时，重组组织型纤溶酶原激活剂组16只眼（100%）视网膜静脉通畅，而生理盐水组1只眼（8.3%）视网膜静脉通畅。结果表明，组织型纤溶酶原激活剂对实验性视网膜静脉血栓有溶解作用。视网膜9：1-7，1989
colon; The thrombolytic effect of recombinant tissue plasminogen activator was studied in 28 randomly selected rabbit eyes to lyse photochemically induced retinal vein occlusion. Occlusion was confirmed histologically and assessed by fluorescein angiography. Sixteen eyes were treated with recombinant tissue plasminogen activator given intravenously and 12 control eyes were given similar volumes of normal saline solution. Fluorescein angiography was performed before and at various intervals after treatment. Four hours after treatment, the retinal vein was patent in 16 eyes (100%) treated with recombinant tissue plasminogen activator, as opposed to one eye (8.3%) treated with normal saline. The results indicate that tissue plasminogen activator is effective in lysing experimentally induced retinal vein thrombi. RETINA 9: 1-7, 1989