Reproducibility of thalamic segmentation based on probabilistic tractography
Reproducibility of thalamic segmentation based on probabilistic tractography
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DOI：
10.1016/j.neuroimage.2010.04.024
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发表时间：
2010-08-01
期刊：
影响因子：
5.7
通讯作者：
Richardson, Mark P.
中科院分区：
文献类型：
--
作者：
Traynor, Catherine;Heckemann, Rolf A.;Richardson, Mark P.
需要可靠地识别丘脑核以改善脑深部刺激（DBS）中使用的电极的靶向，并探索丘脑在健康和疾病中的作用。实施了一种先前描述的方法，该方法使用概率纤维束描记术基于与皮质靶区域的连接来分割丘脑。通过所得分割的重叠来定量评估受试者内和受试者间的再现性，两个不同数量的靶区域的效果当使用不同的起始条件多次处理单个数据集时，观察到非常高的再现性。当使用六个皮质目标区域处理来自同一受试者的多个数据集时，丘脑分割也是非常可再现的。当目标区域的数量增加时，对象再现性降低，特别是在丘脑的内侧和后部区域中。获得了来自不同对象的分割结果的大程度重叠，特别是在被分类为连接到额叶，顶叶，颞叶和中央前皮质靶区（C）2010 Elsevier Inc版权所有
Reliable identification of thalamic nuclei is required to improve targeting of electrodes used in Deep Brain Stimulation (DBS), and for exploring the role of thalamus in health and disease A previously described method using probabilistic tractography to segment the thalamus based on connections to cortical target regions was implemented Both within- and between-subject reproducibility were quantitatively assessed by the overlap of the resulting segmentations, the effect of two different numbers of target regions (6 and 31) on reproducibility of the segmentation results was also investigated Very high reproducibility was observed when a single dataset was processed multiple times using different starting conditions Thalamic segmentation was also very reproducible when multiple datasets from the same subject were processed using six cortical target regions Within-subject reproducibility was reduced when the number of target regions was increased, particularly in medial and posterior regions of the thalamus A large degree of overlap in segmentation results from different subjects was obtained, particularly in thalamic regions classified as connecting to frontal, parietal, temporal and pre-central cortical target regions (C) 2010 Elsevier Inc All rights reserved