Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila.
Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila.
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通过 Hh 信号传导的肠道与神经元相互作用调节果蝇肠道祖细胞分化
DOI：
10.1038/celldisc.2015.6
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发表时间：
2015
期刊：
影响因子：
33.5
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Han H;Pan C;Liu C;Lv X;Yang X;Xiong Y;Lu Y;Wu W;Han J;Zhou Z;Jiang H;Zhang L;Zhao Y
肠道内稳态由肠道干细胞（ISCs）及其后代维持。复杂的自主神经系统遍布后肠。然而，神经元是否以及如何调节后肠稳态在很大程度上是未知的。在这里，我们报告说，神经元调节果蝇后肠稳态。具体地，下调神经元Hedgehog（Hh）信号传导抑制ISCs向肠上皮细胞（EC）的分化，而上调神经元Hh信号传导促进这种过程。我们证明，在多种来源的Hh配体，由EC分泌的诱导类似的表型神经元Hh。此外，肠道JAK/STAT信号对激活的神经元Hh信号作出响应，表明JAK/STAT信号在肠道中作用于神经元Hh信号的下游。总的来说，我们的研究结果表明，神经元Hh信号是至关重要的ISC命运的决定。
Intestinal homeostasis is maintained by intestinal stem cells (ISCs) and their progenies. A complex autonomic nervous system spreads over posterior intestine. However, whether and how neurons regulate posterior intestinal homeostasis is largely unknown. Here we report that neurons regulate Drosophila posterior intestinal homeostasis. Specifically, downregulation of neuronal Hedgehog (Hh) signaling inhibits the differentiation of ISCs toward enterocytes (ECs), whereas upregulated neuronal Hh signaling promotes such process. We demonstrate that, among multiple sources of Hh ligand, those secreted by ECs induces similar phenotypes as does neuronal Hh. In addition, intestinal JAK/STAT signaling responds to activated neuronal Hh signaling, suggesting that JAK/STAT signaling acts downstream of neuronal Hh signaling in intestine. Collectively, our results indicate that neuronal Hh signaling is essential for the determination of ISC fate.