Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications.
Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications.
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DOI：
10.3389/fimmu.2023.1271669
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发表时间：
2023
影响因子：
7.3
通讯作者：
He, Shiming
中科院分区：
文献类型：
--
作者：
Rui, Rui;Zhou, Liqun;He, Shiming
肾细胞癌（Renal cell carcinoma，RCC）是泌尿系统恶性肿瘤之一。目前，肾癌的早期诊断缺乏分子标记物。早期肾细胞癌的5年生存率通常是有利的;然而，当肿瘤进展到远处转移时，预后显著下降。因此，寻找肾癌的分子标志物对提高肾癌的早期诊断率至关重要。外泌体是一种细胞外囊泡（extracellular vesicle，EV），大小在30 nm ~ 150 nm之间，含有RNA、DNA、蛋白质、脂质等，可通过自分泌或旁分泌途径影响邻近受体细胞，影响细胞通讯，调节局部免疫细胞，从而塑造肿瘤免疫微环境，与肿瘤发生发展密切相关。外泌体作为肿瘤标志物和治疗靶点的临床应用在研究界引起了极大的兴趣。本文综述了肾癌外泌体的研究进展。
Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC. The 5-year survival rate for early-stage RCC is generally favorable; however, the prognosis takes a significant downturn when the tumor progresses to distant metastasis. Therefore, the identification of molecular markers for RCC is crucial in enhancing early diagnosis rates. Exosomes are a type of extracellular vesicle (EV) typically ranging in size from 30 nm to 150 nm, which contain RNA, DNA, proteins, lipids, etc. They can impact neighboring receptor cells through the autocrine or paracrine pathway, influence cellular communication, and regulate the local immune cells, consequently shaping the tumor immune microenvironment and closely associating with tumor development. The clinical application of exosomes as tumor markers and therapeutic targets has ignited significant interest within the research community. This review aims to provide a comprehensive summary of the advancements in exosome research within the context of RCC.
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