The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons
The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons
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DOI：
10.1523/jneurosci.3635-09.2010
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发表时间：
2010-02-03
影响因子：
5.3
通讯作者：
Koch, Christof
中科院分区：
文献类型：
--
作者：
Anastassiou, Costas A.;Montgomery, Sean M.;Koch, Christof
神经元和神经胶质的合作行动产生电场，但它们通过ephaptic相互作用对单个神经元的影响大多是未知的。在这里，我们分析了空间不均匀电场对膜电位，诱导膜场和一维电缆以及形态逼真的神经元的诱导电流源密度的影响，并讨论了胞外场的特征如何影响这些量。我们通过模拟表明，内源性领域，与海马θ波和尖波，可以大大影响尖峰时间。这些发现意味着，由脑细胞的合作行动产生的局部电场可以影响神经活动的时间。
The cooperative action of neurons and glia generates electrical fields, but their effect on individual neurons via ephaptic interactions is mostly unknown. Here, we analyze the impact of spatially inhomogeneous electric fields on the membrane potential, the induced membrane field, and the induced current source density of one-dimensional cables as well as morphologically realistic neurons and discuss how the features of the extracellular field affect these quantities. We show through simulations that endogenous fields, associated with hippocampal theta and sharp waves, can greatly affect spike timing. These findings imply that local electric fields, generated by the cooperative action of brain cells, can influence the timing of neural activity.