Erythrocyte aggregation--determination of normal values. Influence of age, sex, hormonal state, oestroprogestative treatment, haematological parameters and cigarette smoking.
Erythrocyte aggregation--determination of normal values. Influence of age, sex, hormonal state, oestroprogestative treatment, haematological parameters and cigarette smoking.
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红细胞聚集——正常值的测定。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
J. Stoltz
中科院分区：
文献类型：
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作者：
B. Pignon;D. Jolly;G. Potron;B. Lartigue;J. Vilque;P. Nguyên;J. Etienne;J. Stoltz
红细胞聚集是一种生理现象，是正常人血液非牛顿性质的重要原因之一。病理学方面也有描述，并提出了旨在降低高聚集性的治疗。本研究的目的是建立正常值的红细胞聚集参数测量激光背散射和研究各种生理因素的影响。正常值由参考人群确定。性别和年龄诱导红细胞聚集的变化，这既不是纤维蛋白原，也不是红细胞压积依赖性的，有一个总体趋势，在妇女更强的聚集，虽然激素状态或雌孕激素治疗似乎影响女性聚集参数。在老年人中也观察到更强的聚集，但这种效应的程度较低。在体内，血浆纤维蛋白原水平是影响红细胞聚集的最重要因素，而红细胞压积的变化起较小的作用，平均红细胞体积、红细胞分布宽度和白色血细胞和血小板计数没有影响。最后，在吸烟者中没有发现差异。
Erythrocyte aggregation is a physiological phenomenon and constitutes one of the most important factors accounting for the non-Newtonian properties of normal human blood. Pathological aspects have also been described and therapy aimed at reducing hyperaggregability has been proposed. The object of this study was to establish normal values of erythrocyte aggregation parameters as measured by laser light backscattering and to study the influence of various physiological factors. Normal values were determined from a reference population. Sex and age induce variations in erythrocyte aggregation which are neither fibrinogen nor haematocrit dependent and there is a general trend towards stronger aggregation in women, although neither hormonal state nor oestroprogestative treatment appear to influence the female aggregation parameters. In elderly people stronger aggregation is also observed but this effect is of lower magnitude. In vivo, the plasma fibrinogen level is the most important factor influencing erythrocyte aggregation, while variations in haematocrit play a lesser role and mean corpuscular volume, red cell distribution width and white blood cell and platelet counts have no effect. Finally, no difference is noted in cigarette smokers.