ADOLESCENT EXPOSURE TO COCAINE INCREASES ANXIETY-LIKE BEHAVIOR AND INDUCES MORPHOLOGIC AND NEUROCHEMICAL CHANGES IN THE HIPPOCAMPUS OF ADULT RATS
ADOLESCENT EXPOSURE TO COCAINE INCREASES ANXIETY-LIKE BEHAVIOR AND INDUCES MORPHOLOGIC AND NEUROCHEMICAL CHANGES IN THE HIPPOCAMPUS OF ADULT RATS
复制标题
青少年接触可卡因会增加成年大鼠的焦虑样行为，并引起海马形态和神经化学变化
DOI：
10.1016/j.neuroscience.2015.11.041
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发表时间：
2016-01-28
期刊：
影响因子：
3.3
通讯作者：
Guan, X.
中科院分区：
文献类型：
--
作者：
Zhu, W.;Mao, Z.;Guan, X.
青少年时期反复接触可卡因可能会影响大脑的生理和心理状况，并增加成年后精神疾病和成瘾行为的风险。青春期是海马体发育的关键时期。此外，海马体的不同区域参与不同的功能。背侧海马（dHP）参与学习和记忆，而腹侧海马（vHP）在情绪加工中起重要作用。在本研究中，在青春期（出生后，P28-P42）暴露于可卡因的大鼠在成年后的升高+迷宫测试中表现出更高的焦虑样行为（P80），但在Morris水迷宫测试中表现出正常的空间学习和记忆。此外，在青春期反复接触可卡因会导致成年大鼠dHP和vHP中锥体神经元的形态、星形胶质细胞的活动以及参与突触传递、凋亡、炎症和成瘾的蛋白质水平的改变。这些发现表明，在大鼠青春期反复接触可卡因可能会导致成年后海马的形态和神经化学变化。这些变化可能导致成人对精神疾病和成瘾的易感性增加。(c) 2015年。Elsevier Ltd.出版。版权所有。
Repeated exposure to cocaine during adolescence may affect both physical and psychological conditions in the brain, and increase the risk of psychiatric disorders and addiction behaviors in adulthood. Adolescence represents a critical development period for the hippocampus. Moreover, different regions of the hippocampus are involved in different functions. Dorsal hippocampus (dHP) has been implicated in learning and memory, whereas ventral hippocampus (vHP) plays an important role in emotional processing. In this study, the rats that were exposed to cocaine during adolescence (postnatal days, P28-P42) showed higher anxiety-like behavior in the elevated plus maze test in adulthood (P80), but displayed normal spatial learning and memory in the Morris water maze test. Furthermore, repeated exposure to cocaine during adolescence lead to alterations in morphology of pyramidal neurons, activities of astrocytes, and levels of proteins that involved in synaptic transmission, apoptosis, inflammation and addiction in both dHP and vHP of adult rats. These findings suggest that repeated exposure to cocaine during adolescence in rats may elicit morphologic and neurochemical changes in the hippocampus when the animals reach adulthood. These changes may contribute to the increased susceptibility for psychiatric disorders and addiction seen in adults. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.