Gender differences in rat neuropathic pain sensitivity is dependent on strain
Gender differences in rat neuropathic pain sensitivity is dependent on strain
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DOI：
10.1016/s0304-3940(00)00880-6
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发表时间：
2000-03-24
影响因子：
2.5
通讯作者：
Rutkowski, MD
中科院分区：
文献类型：
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作者：
DeLeo, JA;Rutkowski, MD
众所周知，性别差异在疼痛敏感性、疼痛报告、止痛效果和某些慢性疼痛障碍的患病率方面起着重要作用。在本研究中，我们试图确定两个不同近交系(Spraogue-Dawley和Holtzman)的雄性或雌性大鼠在同一单神经病变损伤后是否表现出不同的疼痛敏感性。在基线机械痛觉异常测试之后，不同性别和品系的大鼠都接受了L5脊神经横断术。在术后第1、3、5、7和10天分别评估使用2和12g von Frey纤维的机械性痛觉过敏。在Holtzman品系中，不同性别之间或不同品系之间的痛觉异常没有统计学意义上的差异。然而，在接受脊髓神经横断术后，雌性SD大鼠比雄性大鼠的机械性超敏反应明显更严重。这些数据表明，在实验性神经病理性疼痛研究中，特别是在评估潜在的镇痛剂时，应该考虑大鼠性别和品系的选择。(C)2000爱思唯尔爱尔兰科学有限公司。保留所有权利。
It is well recognized that gender differences play a major role in pain sensitivity, pain report, analgesic efficacy and prevalence of certain chronic pain disorders. In the present study we sought to determine whether male or female rats of two different outbred strains (Sprague-Dawley and Holtzman) experienced differential pain sensitivity after the same mononeuropathy lesion. Following baseline mechanical allodynia testing, rats of each sex and strain underwent an L5 spinal nerve transection. Mechanical allodynia using 2 and 12 g von Frey filaments was assessed at days 1, 3, 5, 7, and 10 post surgery. There were no statistically significant differences in allodynia between gender in the Holtzman strain or between strains. However, mechanical allodynia was significantly greater in female Sprague-Dawley rats as compared with males following a spinal nerve transection. These data suggest that the choice of rat gender and strain should be considered in experimental neuropathic pain studies, especially in the assessment of potential analgesics. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.