Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles
Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles
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DOI：
10.1007/s10815-010-9439-y
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发表时间：
2010-09-01
影响因子：
3.1
通讯作者：
Polotsky, Alex J.
中科院分区：
文献类型：
--
作者：
Keltz, Julia;Zapantis, Athena;Polotsky, Alex J.
为了评估男性体重增加是否影响辅助生殖技术后的成功率，对290个周期进行了回顾性研究。男性体重指数大于25.0 kg/m2与临床妊娠率显著降低相关（53.2%对33.6%）。多变量logistic回归分析表明，如果男性伴侣在体外受精后超重，临床妊娠的可能性会降低，但在卵胞浆内单精子注射后则不会（优势比：0.21 [0.07-0.69] vs. 0.75 [0.38-1.49]）。在该队列中，男性伴侣的超重状态与体外受精后临床妊娠可能性的降低独立相关，但与卵胞浆内单精子注射后无关。在调整精子浓度后，观察到较高的男性体重的不利影响，这表明胞浆内单精子注射可能克服一些肥胖相关的精卵相互作用的损害。
To evaluate if elevated male body mass influences success after assisted reproductive technologiesRetrospective study of 290 cycles.Male body mass index greater than 25.0 kg/m(2) was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07-0.69] vs. 0.75 [0.38-1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass.In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.