The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes.
The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes.
复制标题
霍普植物雌激素（8-丙烯基宁）在绝经的动物模型中逆转了卵巢切除术引起的皮肤温度升高。
DOI：
10.1677/joe.1.06919
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发表时间：
2006-11
影响因子：
4
通讯作者：
O'Byrne, Kevin
中科院分区：
文献类型：
--
作者：
Bowe, James;Li, Xiao Feng;Kinsey-Jones, James;Heyerick, Arne;Brain, Susan;Milligan, Stuart;O'Byrne, Kevin
The mechanisms underlying menopausal hot flushes are poorly understood, although it is generally assumed they result from disturbances of thermoregulatory centres in the hypothalamus. 8-prenylnaringenin (8-PN) has been identified as a potent phytoestrogen in hops (Humulus lupulus) and there are claims that hop-containing preparations can reduce hot flushes. We have investigated the site of action of 8-PN in a rat model of menopausal hot flushes, in which the tail skin temperature (TST) is increased after oestrogen withdrawal induced by ovariectomy. Daily subcutaneous administration of either 17β-oestradiol (E2; 4 μg/kg) or 8-PN (400 μg/kg) significantly reduced the elevated TST after 2 days of treatment. Subcutaneous co-administration of either E2 or 8-PN with the oestrogen receptor (ER) antagonist, ICI 182,780 (200 μg/kg), which is thought not to cross the blood-brain-barrier, completely blocked the effect of E2 and 8-PN on TST. The ERα and ERβ specific agonists, PPT (100 μg/kg) and DPN (60 μg/kg) respectively, both significantly reversed the raised TST in ovariectomised rats. These observations suggest that the regulation of the vasomotor response by oestrogens and phytoestrogens is mediated, at least in part, by peripheral mechanisms involving both ERα and ERβ.
