Genome-Wide Association Study of Orthostatic Hypotension and Supine-Standing Blood Pressure Changes in Two Korean Populations
Genome-Wide Association Study of Orthostatic Hypotension and Supine-Standing Blood Pressure Changes in Two Korean Populations
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DOI：
10.5808/gi.2013.11.3.129
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发表时间：
2013-09-01
影响因子：
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通讯作者：
Kim, Yeonjung
中科院分区：
文献类型：
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作者：
Hong, Kyung-Won;Kim, Sung Soo;Kim, Yeonjung
直立性低血压(OH)的定义是仰卧位和站立位之间的收缩压差(DtSBP)为20 mm Hg和/或舒张压差为10 mm Hg，而体位性低血压与心血管反射不能从仰卧位维持血压有关。为了了解OH性状(OH、dtSBP和dtDBP)的潜在遗传因素，对安颂(n=3,173)和安三(n=3,255)两个群体分别进行了333,651个单核苷酸多态性(SNPs)的全基因组关联研究(GWASs)。我们确定了8个SNP(dtSBP的5个SNP和dtDBP的3个SNP)，这些SNP在安成和安山两个队列中都重复关联，其p值为
Orthostatic hypotension (OH) is defined by a 20-mm Hg difference of systolic blood pressure (dtSBP) and/or a 10-mm Hg difference of diastolic blood pressure (dtDBP) between supine and standing, and OH is associated with a failure of the cardiovascular reflex to maintain blood pressure on standing from a supine position. To understand the underlying genetic factors for OH traits (OH, dtSBP, and dtDBP), genome-wide association studies (GWASs) using 333,651 single nucleotide polymorphisms (SNPs) were conducted separately for two population-based cohorts, Ansung (n = 3,173) and Ansan (n = 3,255). We identified 8 SNPs (5 SNPs for dtSBP and 3 SNPs for dtDBP) that were repeatedly associated in both the Ansung and Ansan cohorts and had p-values of