Barriers to Oral Medication Adherence for Adolescents with Inflammatory Bowel Disease
Barriers to Oral Medication Adherence for Adolescents with Inflammatory Bowel Disease
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DOI：
10.1093/jpepsy/jsp085
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发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
Hommel, Kevin A.
中科院分区：
文献类型：
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作者：
Ingerski, Lisa M.;Baldassano, Robert N.;Hommel, Kevin A.
目的确定青少年炎症性肠病（IBD）患者家庭报告的依从性相关障碍，并研究其与6-MP/硫唑嘌呤和5-阿萨药物依从性的关系。方法研究对象为74名13-17岁的IBD青少年及其照顾者。青少年和照顾者共同完成了一项衡量药物依从性障碍的措施。通过家庭报告、药丸计数和血清测定来测量药物依从性。结果家庭赞同1至7个总的障碍，服药依从性。最常报告的障碍包括遗忘、离家和干扰活动。人口统计学变量和疾病严重程度变量均与报告的障碍总数无关。较少的总报告的障碍，更好地遵守青少年和孕产妇的报告。结论：大多数家庭经历至少一个障碍，治疗依从性。围绕这些障碍有效解决问题并将其整合到未来的治疗方案中，可能有助于提高儿童IBD人群的药物依从性。
Objective To identify family-reported, adherence-related barriers for adolescents with inflammatory bowel disease (IBD) and examine their relationship to 6-MP/azathioprine and 5-ASA medication adherence. Methods Participants included 74 adolescents, aged 13-17 years, diagnosed with IBD and their caregivers. Adolescents and caregivers jointly completed a measure of barriers to medication adherence. Adherence to medication was measured by family-report, pill-count, and serum assay. Results Families endorsed one to seven total barriers to medication adherence. The most commonly reported barriers included forgetting, being away from home, and interference with an activity. Neither demographic nor disease severity variables were related to the total number of reported barriers. Fewer total reported barriers was related to better adherence by adolescent and maternal report. Conclusion Most families experience at least one barrier to treatment adherence. Effective problem-solving around these barriers and its integration into future treatment protocols may help improve medication adherence in the pediatric IBD population.