The type 2 human somatostatin receptor as a platform for reporter gene imaging.
The type 2 human somatostatin receptor as a platform for reporter gene imaging.
复制标题
2 型人类生长抑素受体作为报告基因成像的平台。
DOI：
10.1007/s00259-002-0764-y
复制
发表时间：
2002
影响因子：
9.1
通讯作者：
Chaudhuri,TandraR
中科院分区：
文献类型：
--
作者：
Zinn,KurtR;Chaudhuri,TandraR
The human somatostatin receptor subtype 2A (hSSTr2) is under evaluation as a reporter gene for molecular imaging applications. Two approved somatostatin analogues are already available for imaging expression of the reporter gene following delivery with adenoviral (Ad) vectors or other genetic targeting strategies. In animal models, Ad-mediated expression of hSSTr2 in subcutaneous and intraperitoneal tumors was detected by non-invasive gamma camera imaging. This review discusses the rationale and strategy for using thehSSTr2reporter gene as a platform for imaging applications.
