Influence of Maternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Socioemotional Behaviors in Offspring Rats.
Influence of Maternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Socioemotional Behaviors in Offspring Rats.
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DOI：
10.4137/ehi.s10346
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发表时间：
2013
影响因子：
2.7
通讯作者：
Nishijo H
中科院分区：
文献类型：
--
作者：
Nguyen AT;Nishijo M;Hori E;Nguyen NM;Pham TT;Fukunaga K;Nakagawa H;Tran AH;Nishijo H
以往在人类和动物身上进行的研究，均曾报告二恶英对认知功能的影响。在本研究中，我们调查了怀孕期间接触二恶英对社交互动和后代活动的影响，这与神经发育障碍有关。此外，我们分析了大鼠大脑边缘系统的神经化学变化，提出二恶英影响脑功能的机制之一。我们相信这份手稿适合发表在《环境健康洞察》上，因为它为全球广大读者提供了一个有趣的话题。为了阐明母体二恶英暴露与大鼠后代社会情感功能之间的关系，在妊娠第15天给予母鼠TCDD（1.0 μg/kg）。社会互动和强迫游泳时间进行了比较TCDD暴露和对照组的后代在每一个性别。运动的频率和持续时间较高，每次行为的接近和社会接触的持续时间显着降低暴露的男性，而只有接近的持续时间较低的暴露的女性。第一天的强迫游泳时间在暴露的男性显着更长。在大鼠脑边缘系统中，暴露后代中雄性大鼠CaMKIIα的水平和/或活性降低，雌性大鼠CaMKIIα的水平和/或活性升高。这些结果表明，产前TCDD暴露诱导多动症和社会情感缺陷，特别是在男性后代，由于大脑边缘系统中的CaMKIIα活性的改变。
Effects of dioxins on cognitive functions were reported in previous studies conducted in humans and animals. In the present study, we investigated the influence of dioxin exposure during pregnancy on social interaction and on the activity of offspring, which are related to neurodevelopmental disturbances. In addition, we analyzed neurochemical alterations of the limbic system of rat brains to suggest one mechanism of dioxin effects on brain function. We believe that this manuscript is suitable for publication in “Environmental Health Insights” because it provides an interesting topic for a wide global audience. To clarify the relationships between maternal dioxin exposure and socioemotional functions of rat offspring, dams were given TCDD (1.0 μg/kg) on gestational day 15. Social interactions and forced swimming time were compared between TCDD-exposed and control offspring in each gender. Frequency and duration of locomotion were higher, and durations per one behavior of proximity and social contact were significantly lower in the exposed males, while only the duration of proximity was lower in the exposed females. Forced swimming time on the first day was significantly longer in the exposed males. In the limbic system of the rat brain, the levels and/or activity of CaMKIIα were decreased in males and were increased in females in the exposed offspring. These results suggest that prenatal TCDD exposure induces hyperactivity and socioemotional deficits, particularly in the male offspring due to alterations in CaMKIIα activity in the limbic system of the brain.