AIDS-ASSOCIATED NON-HODGKIN LYMPHOMA
AIDS-ASSOCIATED NON-HODGKIN LYMPHOMA
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DOI：
10.1016/0140-6736(91)92513-2
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发表时间：
1991-04-06
期刊：
影响因子：
168.9
通讯作者：
JAFFE, H
中科院分区：
文献类型：
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作者：
BERAL, V;PETERMAN, T;JAFFE, H
非霍奇金淋巴瘤与HIV感染有关。 我们通过分析1989年6月30日之前向美国亚特兰大疾病控制中心报告的病例数据，调查了艾滋病相关非霍奇金淋巴瘤的流行病学和病因学。 在此期间，报告了97258例艾滋病病例，其中2824例（2.9%）为非霍奇金淋巴瘤。 这种情况在艾滋病患者中的发生率是美国普通人群的60倍。 免疫母细胞性淋巴瘤1686例，脑原发性淋巴瘤548例，伯基特淋巴瘤590例，伯基特淋巴瘤是一种通常与免疫抑制无关的疾病，艾滋病患者中免疫母细胞性淋巴瘤的比例从1岁以下的0%上升到50岁以上的3.5%。 所有年龄段的脑原发性淋巴瘤均为0.6%。 伯基特淋巴瘤的发生率从婴儿的零增加到10-19岁的高峰（1.8%）。 每种类型的淋巴瘤在白人中的发病率是黑人的两倍，男性是女性的两倍。 淋巴瘤最常见于血友病或凝血功能障碍患者，最不常见于那些出生在加勒比海或非洲的人，他们通过异性接触感染了HIV。流行病学数据表明，虽然感染因子（如EB病毒）可能与艾滋病患者非霍奇金淋巴瘤的发生有关，但可能没有单一的原因导致所有类型的淋巴瘤。 也许最令人困惑的问题是为什么伯基特淋巴瘤通常与艾滋病毒感染有关，而不是与其他类型的免疫抑制有关。
Non-Hodgkin lymphoma is associated with HIV infection. We investigated the epidemiology and aetiology of AIDS-related non-Hodgkin lymphoma by analysing data from cases reported to the Centers for Disease Control, Atlanta, USA, up to June 30, 1989. During this period 97 258 AIDS cases were reported, of whom 2824 (2.9%) had non-Hodgkin lymphoma. The condition was about 60 times more common in AIDS patients than in the general US population. 1686 cases were immunoblastic lymphoma, 548 primary lymphoma of the brain, and 590 Burkitt's lymphoma, a condition which is not normally associated with immunosuppression.The proportion of AIDS patients with immunoblastic lymphoma increased from 0% in those under 1 year old to 3.5% in those aged 50 or more. Primary lymphoma of the brain was constant at 0.6% for all ages. The frequency of Burkitt's lymphoma increased from zero in infants to a peak at 10-19 years of age (1.8%). Each type of lymphoma was twice as common in whites as in blacks and in men as in women. Lymphoma was most common in patients with haemophilia or clotting disorders and least common in those born in the Caribbean or Africa who had acquired HIV by heterosexual contact.Epidemiological data suggested that whilst infectious agents (eg, Epstein-Barr virus) may be associated with development of non-Hodgkin lymphomas in AIDS patients there was probably no single cause for all the types of lymphoma. Perhaps the most puzzling question is why Burkitt's lymphoma is commonly associated with HIV infection but not with other types of immunosuppression.