The resorption of nanocrystalline calcium phosphates by osteoclast-like cells
The resorption of nanocrystalline calcium phosphates by osteoclast-like cells
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DOI：
10.1016/j.actbio.2010.03.003
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发表时间：
2010-08-01
影响因子：
9.7
通讯作者：
Epple, M.
中科院分区：
文献类型：
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作者：
Detsch, R.;Hagmeyer, D.;Epple, M.
含碳酸盐的纳米晶磷酸钙与骨矿物有很高的相似性，骨细胞(原代成骨细胞和破骨细胞样细胞)在这些材料上以及在烧结的β-磷酸三钙和羟基磷灰石(HA)上的反应证实了纳米晶样品具有良好的生物相容性，但在富碳酸盐样品上破骨细胞的分化受到限制，导致材料上有少量的破骨细胞样细胞和很少的吸收坑。从物理化学角度考虑，磷酸钙陶瓷的颗粒尺寸(纳米级与微米级)没有预期的那么重要。当比较纳米晶样品时，发现低碳酸盐含量的纳米羟基磷灰石的吸收率最高，这强烈地刺激了其表面的破骨细胞样细胞的分化(C)由Elsevier Ltd出版的2010年材料学报版权所有
Nanocrystalline calcium phosphates containing carbonate have a high similarity to bone mineral The reactions of bone cells (primary osteoblasts and osteoclast-like cells) on these materials as well as on sintered beta-tricalcium phosphate and hydroxyapatite (HA) confirmed a good biocompatibility of the nanocrystalline samples However, osteoclastic differentiation was constrained on the carbonate-rich samples, leading to a small number of osteoclast-like cells on the materials and few resorption pits. The grain size of the calcium phosphate ceramics (nano vs micro) was less important than expected from to physico-chemical considerations. When comparing the nanocrystalline samples, the highest resorption rate was found for nano-HA with a low carbonate content, which strongly stimulated the differentiation of osteoclast-like cells on its surface (C) 2010 Acta Materialia Inc Published by Elsevier Ltd All rights reserved