Diverging prognostic impacts of hypoxic markers according to NSCLC histology
Diverging prognostic impacts of hypoxic markers according to NSCLC histology
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DOI：
10.1016/j.lungcan.2010.10.006
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发表时间：
2011-06-01
期刊：
影响因子：
5.3
通讯作者：
Bremnes, Roy M.
中科院分区：
文献类型：
--
作者：
Andersen, Sigve;Eilertsen, Marte;Bremnes, Roy M.
背景：我们的目的是探讨缺氧诱导因子 (HIF α s) 1-2 和代谢性 HIF 调节的葡萄糖转运蛋白 GLUT1、乳酸脱氢酶 5 (LDH5) 和碳酸酐酶 IX (CAIX) 对非小细胞肺癌 (NSCLC) 的预后影响。方法：获得 335 例未经选择的 I-IIIA 期 NSCLC 患者的肿瘤和基质组织样本，并构建组织微阵列。使用免疫组织化学评估表达。结果：对于鳞状细胞癌患者，HIFI 的肿瘤细胞高表达和 HIF1 α 和 HIF2 α 的基质细胞低表达与单变量中较差的疾病特异性生存 (DSS) 显着相关（肿瘤 HIF1 α，P=0.001；基质 HIF1 α，P=0.009；基质 HIF2 α， P=0.005）和多变量分析（肿瘤 HIF1 α，HR=3.3，P=0.001；基质 HIF1 α，HR=2.1，P=0.008；基质 HIF2 α，HR 2.3，P=0.005）。在腺癌患者中，在单变量（GLUT1，P=0.01；LDH5，P=0.03）和多变量分析（GLUT1，HR=1.9，P=0.046；LDH5，HR=2.3，P=0.03）分析中，GLUT]的肿瘤高表达和LDH5的低基质表达与较差的DSS显着相关。结论：这些标志物显示出高度不同的预后NSCLC 中组织学亚组之间以及肿瘤和基质区室之间的影响。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Background: We aimed to explore the prognostic impact of the hypoxia induced factors (HIF alpha s) 1-2 and the metabolic HIF-regulated glucose transporter GLUT1, lactate dehydrogenase 5 (LDH5) and carbonic anhydrase IX (CAIX) in non-small cell lung cancer (NSCLC).Methods: Tumor and stroma tissue samples from 335 unselected patients with stage I-IIIA NSCLC were obtained and tissue microarrays constructed. Immunohistochemistry was used to evaluate expression.Results: For squamous cell carcinoma patients, high tumor cell expression of HIFI and low stromal cell expression of HIF1 alpha and HIF2 alpha correlated significantly with a poor disease-specific survival (DSS) in both univariate (tumor HIF1 alpha, P=0.001; stromal HIF1 alpha, P=0.009; stromal HIF2 alpha, P=0.005) and multivariate analyses (tumor HIF1 alpha, HR=3.3, P=0.001; stromal HIF1 alpha, HR=2.1, P=0.008; stromal HIF2 alpha, HR 2.3, P=0.005). Among adenocarcinoma patients high tumor expression of GLUT] and low stromal expression of LDH5 correlated significantly with a poor DSS in both univariate (GLUT1, P=0.01; LDH5, P=0.03) and multivariate analyses (GLUT1, HR=1.9, P=0.046; LDH5, HR=2.3, P=0.03).Conclusion: These markers show highly diverging prognostic impacts between histological subgroups and between tumor and stromal compartments in NSCLC. (C) 2010 Elsevier Ireland Ltd. All rights reserved.