Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs
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DOI：
10.1073/pnas.1420955112
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发表时间：
2015-03-10
影响因子：
11.1
通讯作者：
Rigoutsos, Isidore
中科院分区：
文献类型：
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作者：
Londin, Eric;Loher, Phillipe;Rigoutsos, Isidore
在第一个动物微小RNA(MiRNA)被发现20年后，动物基因组中miRNAs的数量仍然是一个令人头疼的问题。在这里，我们报告了来自13种不同组织类型的1323个短RNA测序样本(RNA-seq)的分析结果。使用严格的阈值标准，我们识别了3,707个具有统计意义的新的成熟miRNAs，错误发现率为
Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types. Using stringent thresholding criteria, we identified 3,707 statistically significant novel mature miRNAs at a false discovery rate of