The metabolic and cardiovascular effects of hyperthyroidism are largely independent of β-adrenergic stimulation
The metabolic and cardiovascular effects of hyperthyroidism are largely independent of β-adrenergic stimulation
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DOI：
10.1210/en.2003-1670
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发表时间：
2004-06-01
期刊：
影响因子：
4.8
通讯作者：
Hollenberg, AN
中科院分区：
文献类型：
--
作者：
Bachman, ES;Hampton, TG;Hollenberg, AN
甲状腺机能亢进和肾上腺素能亢进有许多共同的临床特征，提示相似的致病机制。广泛使用β -肾上腺素能受体拮抗剂（β -受体阻滞剂）治疗甲状腺功能亢进，使人们相信甲状腺激素（TH）过量的生理后果部分是通过β -肾上腺素受体介导的儿茶酚胺信号传导介导的。为了验证这一假设，我们比较了缺乏三种已知β受体受体（β -less）的小鼠与野生型（WT）小鼠对TH过量的反应。虽然与WT小鼠相比，β -缺失小鼠的基线心率较低，但对甲状腺机能亢进的代谢和心血管反应在WT和β -缺失小鼠中是相同的。这些数据表明，TH过量对代谢和心血管的影响在很大程度上与β - ars无关。这些发现表明，β受体阻滞剂治疗甲亢的临床疗效是由于交感神经信号的拮抗作用，而这一过程独立于TH的作用。
Hyperthyroidism and states of adrenergic hyperactivity have many common clinical features, suggesting similar pathogenic mechanisms of action. The widespread use of beta-adrenergic receptor (betaAR) antagonists (beta-blockers) to treat hyperthyroidism has led to the belief that the physiological consequences of thyroid hormone (TH) excess are mediated in part via catecholamine signaling through betaARs. To test this hypothesis, we compared the response to TH excess in mice lacking the three known betaARs (beta-less) vs. wild-type (WT) mice. Although beta-less mice had a lower heart rate at baseline in comparison to WT mice, the metabolic and cardiovascular responses to hyperthyroidism were equivalent in both WT and beta-less mice. These data indicate that the metabolic and cardiovascular effects of TH excess are largely independent of betaARs. These findings suggest that the efficacy of clinical treatment of hyperthyroidism with beta-blockers is due to antagonism of sympathetic signaling, and that this process functions independently of TH action.