Protocol for project MIME: Motivation, inflammation, and Mood in Emerging Adults.
Protocol for project MIME: Motivation, inflammation, and Mood in Emerging Adults.
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项目MIME的协议：新兴成年人的动机，炎症和情绪。
DOI：
10.1016/j.bbih.2022.100520
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发表时间：
2022-12
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越来越多的证据表明，非典型炎症生物学是情绪精神病理学的危险因素。然而，很少有人尝试将炎症纳入现有的社会心理风险框架中。最近使用二次数据分析的工作研究了情绪障碍免疫认知模型的可能性，其中认知缺陷（即对积极或消极情绪的沉思）增加了唤醒相关特征（例如奖励敏感性）对炎症生物学的影响，可能会增加抑郁和躁狂症状的风险。 MIME 项目（新兴成人的动机、炎症和情绪）旨在在新颖的奖励显着压力源（愤怒激励延迟任务，AIDT）的背景下测试该模型。这项由 NIMH 资助的研究将生成一个包含来自美国宾夕法尼亚州一所大型大学的约 100 名本科生的数据集。合格的参与者是通过在线筛选器招募的，年龄必须在 18 至 22 岁之间，英语流利，并成功回答一些旨在测试参与者是否随机回答筛选器问题的项目。符合条件的参与者将被邀请参加现场访问，完成 AIDT、AIDT 前和 AIDT 后 50 分钟的抽血以及自我报告问卷。参与者还在亲自访问两周后完成了一套在线调查问卷。与美国国立卫生研究院院长的呼吁一致，这项研究旨在通过验证一种新颖的奖励显着压力源（与该领域对社会压力源的依赖相反）在情感和免疫应激反应方面的作用，使压力研究中使用的工具多样化。除了这一方法论目标之外，MIME 项目是第一项专门用于测试情绪精神病理学免疫认知模型的研究。鉴于将几个可塑的治疗目标（接近行为、情绪调节、炎症）整合到该模型中，这项研究的结果可以为情绪障碍的预防和治疗提供全面、灵活的干预策略。
Atypical inflammatory biology is gaining evidence as a risk factor for mood psychopathology; however, little work has attempted to integrate inflammation into extant psychosocial frameworks of risk. Recent work using secondary data analysis has investigated the possibility of an immunocognitive model of mood disorders, in which cognitive vulnerabilities (i.e., rumination on positive or negative affect) increase the effect that arousal-related characteristics (e.g., reward sensitivity) have on inflammatory biology in ways that may confer risk for depression and hypo/mania symptoms. Project MIME (Motivation, Inflammation, and Mood in Emerging Adults) was designed to test this model in the context of a novel, reward-salient stressor (the Anger Incentive Delay Task, AIDT). This NIMH-funded study will result in a dataset of approximately 100 college undergraduates from a large university in Pennsylvania, United States of America. Eligible participants are recruited from an online screener, have to be 18–22 years old, fluent in English, and successfully answer several items designed to test whether participants randomly answer questions on the screener. Eligible participants are invited to an in-person visit in which they completed the AIDT, blood draws pre- and 50 minutes post-AIDT, and self-report questionnaires. Participants also complete a set of online questionnaires two weeks after the in-person visit. Consistent with calls from the NIH director, this study seeks to diversify the tools used in stress research by validating a novel reward-salient stressor (in contrast to the field's reliance on social stressors) with respect to affective and immunological stress reactivity. In addition to this methodological goal, Project MIME is the first study specifically designed to test the immunocognitive model of mood psychopathology. Given the integration of several malleable treatment targets (approach behavior, emotion regulation, inflammation) into this model, results from this study could inform comprehensive, flexible intervention strategies for mood disorder prevention and treatment.