Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti.
Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti.
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DOI：
10.1038/ncomms15046
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发表时间：
2017-05-11
影响因子：
16.6
通讯作者：
Xu PX
中科院分区：
文献类型：
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作者：
Xu J;Ueno H;Xu CY;Chen B;Weissman IL;Xu PX
成年哺乳动物的耳蜗感觉上皮有两种主要类型的细胞，机械感觉毛细胞和底层支持细胞，缺乏再生能力。最近的证据表明，只有在产后第一周内，支持细胞的一部分才能在消融后自发再生毛细胞。在此，对发育过程中的小鼠内耳细胞进行的体内克隆分析表明，毛发和感官中的支持细胞之间存在克隆关系。我们报告了在小鼠身上发现了一组以前未知的多能干/祖细胞，这些细胞不仅能够为毛发和支持细胞做出贡献，还能够在耳蜗骨的发育、成熟和修复过程中对损伤做出贡献，包括胶质细胞。这些多能祖细胞来源于表达Eya1的耳源性祖细胞。我们的发现也为出生后1周以上的耳蜗可检测到的再生潜力提供了证据。成年哺乳动物的耳蜗感觉上皮由机械感觉毛细胞和支持细胞组成，但毛细胞不能再生。在这里，作者确定了来自表达Eya1的耳聋细胞的多潜能祖细胞，这些细胞可以在小鼠出生一周后再生毛细胞。
The adult mammalian cochlear sensory epithelium houses two major types of cells, mechanosensory hair cells and underlying supporting cells, and lacks regenerative capacity. Recent evidence indicates that a subset of supporting cells can spontaneously regenerate hair cells after ablation only within the first week postparturition. Here in vivo clonal analysis of mouse inner ear cells during development demonstrates clonal relationship between hair and supporting cells in sensory organs. We report the identification in mouse of a previously unknown population of multipotent stem/progenitor cells that are capable of not only contributing to the hair and supporting cells but also to other cell types, including glia, in cochlea undergoing development, maturation and repair in response to damage. These multipotent progenitors originate from Eya1-expressing otic progenitors. Our findings also provide evidence for detectable regenerative potential in the postnatal cochlea beyond 1 week of age. The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise from Eya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.