Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission
Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission
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使用具有聚集诱导发射的无标记荧光探针噻咯对 G-四链体 DNA 进行目视观察
DOI：
10.1016/j.bmc.2009.09.040
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发表时间：
2009-11-15
影响因子：
3.5
通讯作者：
Zhang, Deqing
中科院分区：
文献类型：
--
作者：
Huang, Jing;Wang, Ming;Zhang, Deqing
AIE分子Silole 1可用于核酸外切酶I水解法检测G-四链体的形成。这种G-四联体的肉眼观察已成功地用于研究多种G-四联体，包括单链端粒、c-myc、c-kit、VEGFG-四联体和一个d(G(4)T(4)G(4))分子间G-四联体。G-四链体的检测也适用于小分子诱导的G-四链体异构体。(C)2009爱思唯尔有限公司。保留所有权利。
AIE molecule silole 1 could be used to detect G-quadruplex formation using an exonuclease I hydrolysis assay. This visual observation of G-quadruplexes has been successfully used in investigating multiple G-quadruplexes, including the one-stranded telomeric, c-myc, c-kit, VEGF G-quadruplexes, and a d(G(4)T(4)G(4)) inter-molecular G-quadruplex. The detection of G-quadruplex can be also applied to G-quadruplex isomers induced by small molecules. (C) 2009 Elsevier Ltd. All rights reserved.