Serum Adiponectin Levels are Associated with Hepatitis B Viral Load in Overweight to Obese Hepatitis B Virus Carriers
Serum Adiponectin Levels are Associated with Hepatitis B Viral Load in Overweight to Obese Hepatitis B Virus Carriers
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DOI：
10.1002/oby.20000
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发表时间：
2013-02-01
期刊：
影响因子：
6.9
通讯作者：
Huang, Kuo-Chin
中科院分区：
文献类型：
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作者：
Chiang, Chien-Hsieh;Lai, Jin-Shin;Huang, Kuo-Chin
目的：本研究旨在探讨血清脂联素与慢性乙型肝炎病毒（HBV）感染之间的关系。设计和方法：我们在乙型肝炎病毒流行国家台湾北部进行了一项校园横断面研究。共有 506 名参与者，包括 147 名慢性 HBV 感染者和 359 名健康对照者，对人体测量指数、血清脂联素水平、血清 HBV 病毒载量和标志物、血清丙氨酸转氨酶水平和代谢因素进行了评估。结果：年龄较大、男性、较高的丙氨酸转氨酶、较高的体重指数、较大的腰围、较低的空腹血糖、较高的甘油三酯和较高的脂联素与慢性乙型肝炎相关。单变量分析中的 HBV 感染。在多变量分析中，慢性乙型肝炎病毒感染的存在与血清脂联素水平呈正相关（P < 0.0001），并且在调整年龄、性别、体重指数和胰岛素抵抗指数后，脂联素水平高于第 75 个百分位数（比值比，4.25；95% 置信区间，2.36-7.66；P < 0.0001）。此外，超重至肥胖HBV感染者的血清脂联素水平与HBV病毒载量呈正相关（P = 0.018）。结论：虽然慢性HBV感染者比健康对照者体重重，但他们的血清脂联素水平显着高于健康对照者。此外，在超重至肥胖的 HBV 感染者中，脂联素水平与 HBV 病毒载量呈正相关。未来的研究应集中于阐明脂联素途径，这可能有助于开发慢性乙型肝炎病毒感染的辅助治疗方法。
Objective: This study aimed to investigate the association between serum adiponectin and chronic hepatitis B virus (HBV) infection.Design and Methods: We conducted a campus-based cross-sectional study in Northern Taiwan, an HBV-endemic country. A total of 506 participants, including 147 chronic HBV-infected individuals and 359 healthy controls, were assessed for anthropometric indices, serum adiponectin levels, serum HBV viral load and markers, serum alanine aminotransferase levels and metabolic factors.Results: Older age, male gender, higher alanine aminotransferase, higher body mass index, greater waist circumference, lower fasting glucose, higher triglycerides, and higher adiponectin were associated with chronic HBV infection in univariate analyses. In multivariate analysis, the presence of chronic HBV infection was positively associated with serum adiponectin levels (P < 0.0001) and high adiponectin levels over the 75th percentile (odds ratio, 4.25; 95% confidence interval, 2.36-7.66; P < 0.0001) after adjusting for age, gender, body mass index, and insulin resistance index. Furthermore, serum adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects (P = 0.018).Conclusion: Although chronic HBV-infected individuals were heavier than healthy controls, they had significantly higher serum adiponectin levels than healthy counterparts. Additionally, adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects. Future research should focus on elucidating adiponectin pathways, which may contribute to the development of adjuvant treatments for chronic HBV infection.