Hydroxyl radical is a significant player in oxidative DNA damage in vivo.

Hydroxyl radical is a significant player in oxidative DNA damage in vivo.
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DOI:
10.1039/d1cs00044f
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发表时间:
2021-08-07
影响因子:
46.2
通讯作者:
Dizdaroglu M
Dizdaroglu M
中科院分区:
化学1区
文献类型:
--
作者:
Halliwell B ;Adhikary A ;Dingfelder M ;Dizdaroglu M

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最近的出版物表明,由羟基自由基(·OH)介导的氧化性DNA损伤在体内并不重要,碳酸根阴离子自由基(CO3·−)起着关键作用。我们检查这些索赔和总结的证据表明,·OH确实发挥了关键作用,作为活性氧(ROS)在体内的重要成员。
Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (•OH) is unimportant in vivo, and that carbonate anion radical (CO3•−) plays the key role. We examine these claims and summarize the evidence that •OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.
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