Neural correlates of response reversal: Considering acquisition
Neural correlates of response reversal: Considering acquisition
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DOI：
10.1016/j.neuroimage.2006.08.060
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发表时间：
2007-02-15
期刊：
影响因子：
5.7
通讯作者：
Blair, R. J. R.
中科院分区：
文献类型：
--
作者：
Budhani, S.;Marsh, A. A.;Blair, R. J. R.
先前关于反应反转的工作通常使用连续反转的单对刺激。这种收购和逆转过程的合并，阻止了检查的功能作用的神经系统参与反应逆转在收购过程中，尽管这些数据的相关性，在评估帐户的反应逆转。在目前的研究中，参与者遇到了16个独立的逆转刺激对的概率反应逆转范式的背景下。通过先前文献中使用的对比（在逆转阶段与奖励的正确反应中所犯的惩罚错误），确定参与反应逆转的感兴趣的功能区域，在不同条件下进行询问。与中额叶皮层编码奖励的建议一致，该区域对奖励的反应显着大于惩罚试验，无论准确性或学习阶段（收购或逆转）。我们观察到杏仁核内的活动与前扣带皮层的吻侧区域之间存在显著的正相关性，该区域与中额叶/内侧前额叶皮层非常接近，这与我们的观点一致，即对强化预期的编码是通过杏仁核的输入获得的。相比之下，下额叶皮层，前扣带皮层和尾状核表现出更大的反应，惩罚错误比奖励正确的反应。这三个区域也表现出显着的激活奖励错误在收购过程中，相反的立场表明，下额叶皮层代表惩罚或抑制以前奖励的反应。此外，与前扣带皮层种子的连接性分析显示，它们之间的正连接性非常显着。这些数据的影响，最近的帐户的反应逆转和反应逆转障碍，在特定的神经精神病人群进行了讨论。爱思唯尔公司出版
Previous work on response reversal has typically used a single pair of stimuli that serially reverse. This conflation of acquisition and reversal processes has prevented an examination of the functional role of neural systems implicated in response reversal during acquisition despite the relevance of such data in evaluating accounts of response reversal. In the current study, participants encountered 16 independent reversing stimulus pairs in the context of a probabilistic response reversal paradigm. Functional regions of interest identified as involved in response reversal through a contrast used in the previous literature (punished errors made in the reversal phase versus rewarded correct responses), were interrogated across conditions. Consistent with suggestions that middle frontal cortex codes reward, this region showed significantly greater responses to rewarded rather than punished trials irrespective of accuracy or learning phase (acquisition or reversal). Consistent with the suggestion that this coding of the expectation of reinforcement is acquired via input from the amygdala, we observed significant positive connectivity between activity within the amygdala and a region of rostral anterior cingulate cortex highly proximal to this region of middle frontal/mesial prefrontal cortex. In contrast, inferior frontal cortex, anterior cingulate cortex and caudate showed greater responses to punished errors than to the rewarded correct responses. These three regions also showed significant activation to rewarded errors during acquisition, in contrast to positions suggesting that inferior frontal cortex represents punishment or suppresses previously rewarded responses. Moreover, a connectivity analysis with an anterior cingulate cortex seed revealed highly significant positive connectivity among them. The implications of these data for recent accounts of response reversal and of response reversal impairments in specific neuropsychiatric populations are discussed. Published by Elsevier Inc.