Ultra-pH-responsive split i-motif based aptamer anchoring strategy for specific activatable imaging of acidic tumor microenvironment
Ultra-pH-responsive split i-motif based aptamer anchoring strategy for specific activatable imaging of acidic tumor microenvironment
复制标题
基于超 pH 响应分裂 i 基序的适体锚定策略，用于酸性肿瘤微环境的特异性可激活成像
DOI：
10.1039/c8cc04420a
复制
发表时间：
2018-09-18
影响因子：
4.9
通讯作者：
Wang, Kemin
中科院分区：
文献类型：
--
作者：
Lei, Yanli;He, Xiaoxiao;Wang, Kemin
A non-blocking split i-motif based aptamer anchoring strategy was developed as a general platform for sensing weakly acidic tumor microenvironment. By rationally tuning the response range to pH 7.0-6.4 and adjusting aptamer types, the strategy achieved specific, pH(e)-activated imaging of different cancers in vitro and in vivo.
