Validation of marrow fat assessment using noninvasive imaging with histologic examination of human bone samples
Validation of marrow fat assessment using noninvasive imaging with histologic examination of human bone samples
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DOI：
10.1016/j.bone.2014.11.002
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发表时间：
2015-03-01
期刊：
影响因子：
4.1
通讯作者：
Hui, Susanta
中科院分区：
文献类型：
--
作者：
Arentsen, Luke;Yagi, Masashi;Hui, Susanta
目的：全身的骨髓成分是不同的，并随着年龄的变化而变化。由于异质性，侵袭性的髂骨活组织检查不能真实地反映完整的生理状态，阻碍了这种方法的临床有效性。因此，我们的目标是利用联合注册的组织学检查为评估骨髓肥胖症提供体内成像技术的验证。方法：最近到期的五项(即0.984。AWRY与成像方式、DECT的MF和wfMRI具有相似的相关性(r分别为0.802和0.772)。结论：25个椎体的MF变异较大。DECT和wfMRI与组织学脂肪细胞比例有很好的相关性，可以用来测量MF。这使得纵向研究成为可能，而不需要痛苦、低效的侵入性活组织检查。(C)2014 Elsevier Inc.保留所有权利。
Purpose: The marrow composition throughout the body is heterogeneous and changes with age. Due to heterogeneity, invasive biopsies of the iliac crest do not truly represent the complete physiological status, impeding the clinical effectiveness of this method. Therefore, we aim to provide verification for an in vivo imaging technique using co-registered histologic examinations for assessment of marrow adiposity.Methods: Five recently expired (i.e. 0.984. There were similar correlations between Awry and the imaging modalities, DECT-derived MF and wfMRI (r = 0.802 and 0.772, respectively).Conclusions: A high MF variation was seen among the 25 vertebrae imaged. Both DECT and wfMRI have a good correlation with the histologic adipocyte proportion and can be used to measure MF. This makes longitudinal studies possible without painful, less-effective, invasive biopsies. (C) 2014 Elsevier Inc. All rights reserved.