Mindfulness-based therapy modulates default-mode network connectivity in patients with opioid dependence
Mindfulness-based therapy modulates default-mode network connectivity in patients with opioid dependence
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DOI：
10.1016/j.euroneuro.2019.03.002
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发表时间：
2019-05-01
影响因子：
5.6
通讯作者：
Wolf, Robert Christian
中科院分区：
文献类型：
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作者：
Fahmy, Reham;Wasfi, Maha;Wolf, Robert Christian
最近，基于正念的计划在治疗物质使用障碍（SUD）方面显示出有希望的临床效果。虽然有几项研究将正念与冥想者的默认模式网络（DMN）连接性降低联系起来，但只有少数研究调查了它对SUD患者的影响。这项研究旨在检测在治疗的第一个月内接受正念治疗（MBT）的阿片类药物依赖患者的DMN连接变化。来自32名被分配到MBT或常规治疗（TAU）组的患者的数据进行了研究，使用静息态功能MRI在1.5 T治疗前后四周。独立成分分析用于研究不同的（前与后）DMN子系统。治疗后的连通性变化与冲动性，痛苦耐受性和正念有关。与TAU相比，接受MBT的患者在治疗后的正念评分增加。在前部DMN内，与TAU相比，接受MBT的患者检测到右下额叶皮质连接性降低。此外，在MBT组内，治疗后检测到右侧上级额叶皮层连接性降低。下额叶皮层功能与正念测量显著相关。这些数据表明，MBT在阿片类药物戒断期间可能有用。在阿片类药物依赖患者中，DMN内不同的功能连接变化与MBT相关。(c)2019 Elsevier B.V.和ECNP。All rights reserved.
Recently, mindfulness-based programs have shown promising clinical effects in the treatment of substance-use disorders (SUD). While several studies linked mindfulness to decreased default mode network (DMN) connectivity in meditators, only a few studies investigated its effects in patients with SUD. This study aimed to detect changes in DMN connectivity in opiate dependent patients receiving mindfulness based therapy (MBT) during their first month of treatment. Data from 32 patients that were assigned to MBT or treatment as usual (TAU) groups was investigated using resting-state functional MRI at 1.5 T before and after four weeks of treatment. Independent Component Analysis was used to investigate distinct (anterior vs. posterior) DMN subsystems. Connectivity changes after treatment were related to measures of impulsivity, distress tolerance and mindfulness. Increased mindfulness scores after treatment were found in patients receiving MBT compared to TAU. Within the anterior DMN, decreased right inferior frontal cortical connectivity was detected in patients who received MBT compared to TAU. In addition, within the MBT-group decreased right superior frontal cortex connectivity was detected after treatment. Inferior frontal cortex function was significantly associated with mindfulness measures. The data suggest that MBT can be useful during abstinence from opiates. In opiate-dependent patients distinct functional connectivity changes within the DMN are associated with MBT. (c) 2019 Elsevier B.V. and ECNP. All rights reserved.