Fluconazole concentrations in pulmonary tissue and pericardial fluid
Fluconazole concentrations in pulmonary tissue and pericardial fluid
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DOI：
10.1007/bf02113615
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发表时间：
1997-05-01
期刊：
影响因子：
7.5
通讯作者：
Sarnow, E
中科院分区：
文献类型：
--
作者：
RiederNelissen, CM;Hasse, J;Sarnow, E
为了探讨三唑类抗真菌药氟康唑（FCA）治疗肺真菌病的临床疗效，本研究测定了氟康唑静脉给药200 mg后1、2、12、13 h人体肺组织、心包液和血清中氟康唑的浓度。血清中FCA平均浓度分别为4.04 mg/l （1 h）、3.82 mg/l （2 h）、2.35 mg/l （12 h）和2.13 mg/l （13 h）。肺组织中FCA含量分别为4.64 mg/kg、4.54 mg/kg；心包液浓度分别为3.86 mg/l、3.57 mg/l、2.35 mg/l和2.13 mg/l。静脉给药后2 h、12 h、13 h肺组织FCA浓度均高于血清浓度，差异有统计学意义（p < 0.05）。
In order to investigate the clinical efficacy of the triazole antifungal agent fluconazole (FCA) in the treatment of pulmonary mycosis, in the present study the concentrations of fluconazole in human pulmonary tissue, pericardial fluid and serum were determined at 1, 2, 12 and 13 h after intravenous administration of fluconazole 200 mg. The mean FCA concentrations in the serum were 4.04 mg/l (1 h), 3.82 mg/l (2 h), 2.35 mg/l (12 h) and 2.13 mg/l (13 h). The respective FCA levels in the pulmonary tissue were 4.64 mg/kg, 4.54 mg/kg; 3.50 mg/kg and 3.40 mg/kg and the concentrations in the pericardial fluid were 3.86 mg/l, 3.57 mg/l, 2.35 mg/l and 2.13 mg/l. The FCA concentrations in the pulmonary tissue that were statistically significant higher than the serum concentrations were found at 2 h, 12 h and 13 h after intravenous administration (p less than 0.05).