Occupational and recreational physical activity during adult life and the risk of cancer among men
Occupational and recreational physical activity during adult life and the risk of cancer among men
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DOI：
10.1016/j.canep.2010.09.004
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发表时间：
2011-04-01
影响因子：
2.6
通讯作者：
Siemiatycki, Jack
中科院分区：
文献类型：
--
作者：
Parent, Marie-Elise;Rousseau, Marie-Claude;Siemiatycki, Jack
背景资料：有强有力的证据表明，体力活动（PA）对结肠癌、乳腺癌（绝经后）和子宫内膜癌具有保护作用，但其他癌症类型的数据不太一致或稀缺。本研究在加拿大蒙特利尔进行的一项基于人群的病例对照研究中评估了职业和娱乐性PA与男性癌症风险之间的关系。研究方法：肺癌（n = 857）、结肠癌（n = 496）、膀胱癌（n = 484）、前列腺癌（n = 449）、胃癌（n = 251）、直肠癌（n = 248）、非霍奇金淋巴瘤（n = 215）、肾癌（n = 177）、胰腺癌（n = 116）、黑色素瘤（n = 103）、食管癌（n = 99），霍奇金淋巴瘤（n = 54），和533人口控制，进行了采访。详细的终身职业PA被翻译成代谢当量。鼓励参加体育和户外活动。结果如下：与那些一生职业PA水平低的人相比，职业PA水平高的男性对所有癌症类型的优势比（OR）都有所下降。最有力的证据是结肠癌[OR：0.58，95%置信区间（CI）：0.34 - 0.99]和前列腺癌（OR：0.54，95% CI：0.31 - 0.95）。从事运动和户外活动的男性患肺结核的风险较低，（OR：0.69，95% CI：0.520.91），食管（OR：0.54，95% CI：0.30 - 0.97）和膀胱（OR：0.78，95%CI：0.59 - 1.05）癌症，并且黑素瘤的风险有所增加（OR：1.24，95%CI：0.73 - 2.12）。结论：观察到高职业PA水平对结肠癌和前列腺癌的保护作用。在其他几种癌症类型中也注意到了反向关联的趋势。Receptor PA与吸烟相关的癌症（包括肺癌、食管癌和膀胱癌）呈负相关。(C)2010爱思唯尔有限公司版权所有。
Background: There is a strong evidence for a protective role of physical activity (PA) on cancers of the colon, breast (postmenopausal) and endometrium, but data are less consistent or scarce for other cancer types. This study assessed the relationship between occupational and recreational PA and cancer risk among men in a population-based case-control study conducted in Montreal, Canada. Methods: Incident cases of cancer of the lung (n = 857), colon (n = 496), bladder (n = 484), prostate (n = 449), stomach (n = 251), rectum (n = 248), non-Hodgkin's lymphoma (n = 215), kidney (n = 177), pancreas (n = 116), melanoma (n = 103), esophagus (n = 99), Hodgkin's lymphoma (n = 54), and 533 population controls, were interviewed. Detailed lifetime occupational PAs were translated into metabolic equivalents. Participation in sports and outdoor activities was elicited. Results: Compared to those with low lifetime occupational PA levels, men with high occupational PA levels had decreased odds ratios (OR) for all cancer types. The strongest evidence was for cancers of the colon [OR: 0.58, 95% confidence interval (Cl): 0.34-0.99] and the prostate (OR: 0.54, 95% CI: 0.31-0.95). Men engaging in sports and outdoor activities had lower risks of lung (OR: 0.69, 95% CI: 0.520.91), esophageal (OR: 0.54, 95% CI: 0.30-0.97) and bladder (OR: 0.78, 95% CI: 0.59-1.05) cancers, and somewhat increased risks of melanoma (OR: 1.24, 95% CI: 0.73-2.12). Conclusions: A protective effect of high lifetime occupational PA levels was observed for colon and prostate cancers. A tendency for inverse associations was also noted for several other cancer types. Recreational PA was inversely related with smoking-related cancers including lung, esophageal and bladder cancers. (C) 2010 Elsevier Ltd. All rights reserved.