Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebocontrolled, double-blind study
Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebocontrolled, double-blind study
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DOI：
10.2147/ccid.s36102
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发表时间：
2012-01-01
影响因子：
2.3
通讯作者：
Marzatico, Fulvio
中科院分区：
文献类型：
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作者：
Buonocore, Daniela;Lazzeretti, Angelo;Marzatico, Fulvio
背景：皮肤持续暴露于多种来源的促氧化环境压力下，包括空气污染物、紫外线和化学氧化剂。活性氧与年龄相关的皮肤疾病有关。饮食中的生物活性抗氧化化合物，如多酚，对皮肤健康有益。营养给药途径的优点是血液将营养生物活性化合物连续地输送到所有皮肤区室，即表皮、真皮层和皮下脂肪。本研究的目的是评估含有白藜芦醇和原花青素的膳食补充剂对皮肤、皮肤抗氧化池和全身氧化应激水平的年龄相关变化的局部和全身影响。方法：对50名受试者（25名服用补充剂，25名服用安慰剂）进行仪器研究，以确定时间老化或光老化引起的临床特征。在治疗60天后，根据体内和原位皮肤水化、弹性和皮肤粗糙度水平、通过活性氧代谢物的血浆衍生物和氧吸附剂测试的全身氧化应激水平以及皮肤抗氧化池的范围来评估产品功效。结果：治疗60 d后，全身氧化应激值、血浆抗氧化能力、皮肤抗氧化能力均显著升高。此外，皮肤的保湿性和弹性有所改善，而皮肤粗糙度和皱纹深度有所减少。老年斑的强度明显降低，个体类型角度的改善证明了这一点。结论：以白藜芦醇和原花青素的特定混合物为特征的营养品和药理学干预可能是一种有希望的策略，可以支持减少皮肤皱纹的治疗，以及减少全身和皮肤氧化应激。
Background: Skin is constantly exposed to pro-oxidant environmental stress from several sources, including air pollutants, ultraviolet solar light, and chemical oxidants. Reactive oxygen species have been implicated in age-related skin disorders. Dietary bioactive antioxidant compounds, such as polyphenols, have beneficial effects on skin health. The advantage of a nutritional administration route is that blood delivers nutraceutical bioactive compounds continuously to all skin compartments, ie, the epidermis, dermis, and subcutaneous fat. The purpose of this study was to evaluate the topical and systemic effects of a dietary supplement containing resveratrol and procyanidin on age-related alterations to the skin, the skin antioxidant pool, and systemic oxidative stress levels.Methods: An instrumental study was performed in 50 subjects (25 treated with supplements and 25 with placebo) to identify clinical features induced by chronoaging or photoaging. Product efficacy was evaluated after 60 days of treatment in terms of in vivo and in situ skin hydration, elasticity, and skin roughness levels, systemic oxidative stress levels by plasmatic derivatives of reactive oxygen metabolites and oxyadsorbent tests, and extent of the skin antioxidant pool.Results: After 60 days of treatment, values for systemic oxidative stress, plasmatic antioxidant capacity, and skin antioxidant power had increased significantly. Additionally, skin moisturization and elasticity had improved, while skin roughness and depth of wrinkles had diminished. Intensity of age spots had significantly decreased, as evidenced by improvement in the individual typological angle.Conclusion: Nutraceutical and pharmacological intervention with a supplement characterized by a specific blend of resveratrol and procyanidin may be a promising strategy to support treatments for the reduction of skin wrinkling, as well as reducing systemic and skin oxidative stress.