Three-component coupling using arynes and aminosilanes for ortho-selective double functionalization of aromatic skeletons.
Three-component coupling using arynes and aminosilanes for ortho-selective double functionalization of aromatic skeletons.
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DOI：
10.1021/jo800761b
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发表时间：
2008-06
期刊：
影响因子：
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通讯作者：
T. Morishita;H. Fukushima;H. Yoshida;J. Ohshita;A. Kunai
中科院分区：
文献类型：
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作者：
T. Morishita;H. Fukushima;H. Yoshida;J. Ohshita;A. Kunai
在苯甲酸存在下，芳烃被发现与氨基硅烷和羰基化合物偶联，生成2-氨基苯。磺酰亚胺也可以应用于反应，使氨基和氨甲基部分结合到芳香骨架的连续位置上。在没有苯甲酸的情况下，只得到了少量的三组分偶联产物，证实了它在本反应中的重要作用。
Arynes were found to couple with aminosilanes and carbonyl compounds in the presence of benzoic acid to provide 2-aminobenzhydrols. Sulfonylimines could also be applied to the reaction, enabling amino and aminomethyl moieties to be incorporated into contiguous positions of aromatic skeletons. Only a small amount of the three-component coupling product was obtained in the absence of benzoic acid, which confirms its vital role in the present reaction.