The growth of the autotransplanted rat incisor tooth odontogenic organ.
The growth of the autotransplanted rat incisor tooth odontogenic organ.
复制标题
自体移植大鼠门牙牙源器官的生长。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
M. Weinreb
中科院分区：
文献类型：
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作者：
Y. Michaeli;G. Zajicek;M. Weinreb
将74只大鼠门牙牙源性器官皮内自体移植到耳廓。嫁接后八个月内，将动物以四只为一组处死。从第三周开始检查的 61 个移植物中，46% 表现出典型的牙源器官或具有牙髓、血管和神经纤维的分化良好的牙齿。 33%仅形成分散的上皮岛。 21% 的移植物最终形成骨牙本质。在最初的创伤导致无菌性坏死后，最原始的牙源性器官细胞存活下来并产生新的牙齿。移植的牙源性器官恢复其作为复杂结构的存在，其从宿主真皮动员其自身的血管和神经供应，这从穿透牙髓的神经纤维可以明显看出。由于移植物的所有原始神经纤维都必须与其细胞体断开，因此它们明显退化。因此，在再生牙髓中观察到的任何神经纤维都必须是真皮来源的。
74 rat incisor odontogenic organs were autotransplanted intradermally into the auricle. The animals were killed in groups of four up to eight months after grafting. Out of 61 grafts examined from the third week onward, 46% exhibited a typical odontogenic organ or a well differentiated tooth with pulp, vessels and nerve fibers. In 33% only scattered epithelial islands were formed. 21% of the grafts ended as osteodentin. Following the initial trauma leading to aseptic necrosis, the most primitive odontogenic organ cells survive to generate a new tooth. The grafted odontogenic organ resumes its existence as a complex structure which mobilizes its own vascular and nervous supply from the host dermis as evident from nerve fibers which penetrated the tooth pulp. Since all original nerve fibers of the graft had to be disconnected from their cell bodies, they obviously degenerated. Thus any nerve fiber observed in the regenerating tooth pulp had to be of dermal origin.