Stress generation over the course of breast cancer survivorship.
Stress generation over the course of breast cancer survivorship.
复制标题
乳腺癌生存过程中压力的产生。
DOI：
10.1007/s10865-010-9255-y
复制
发表时间：
2010
影响因子：
3.1
通讯作者：
Andersen,BarbaraL
中科院分区：
文献类型：
--
作者：
Wu,SaleneM;Andersen,BarbaraL
抑郁症状通常在乳腺癌诊断后升高。压力产生假说指出，抑郁症患者会产生压力事件，这些压力源会导致随后的抑郁症。这项研究在癌症存活的前5年测试了压力产生假说。II期或III期乳腺癌女性（N= 113）。建立了五个调解模式，每年一个。每个模型都测试了每年的压力事件是否介导了当年年初和年末抑郁症之间的关系。在癌症诊断后的前2年内观察到压力产生，但在诊断后的2至5年内没有观察到压力产生。乳腺癌患者抑郁与未来压力的关系可能会受到生存期的影响。癌症幸存者抑郁症状的筛查和治疗可能需要考虑压力事件的产生。
Depressive symptoms are frequently elevated following breast cancer diagnosis. The stress generation hypothesis states that people with depression generate stressful events and these stressors lead to subsequent depression. This study tested the stress generation hypothesis over the first 5 years of cancer survivorship. Women with stage II or III breast cancer (N= 113) were accrued. Five mediation models were constructed, one for each year. Each model tested whether stressful events in each year mediated the relationship between depression at the beginning and end of that year. Stress generation was observed in the first 2 years following cancer diagnosis but not from 2 to 5 years after diagnosis. The relationship of depression to future stress in breast cancer patients may be moderated by phase of survivorship. Screening and treatment of depressive symptoms in cancer survivors may need to consider the generation of stressful events.