Serum antibodies after vaccination with Haemophilus influenzae type b capsular polysaccharide and responses to reimmunization: no evidence of immunologic tolerance or memory.
Serum antibodies after vaccination with Haemophilus influenzae type b capsular polysaccharide and responses to reimmunization: no evidence of immunologic tolerance or memory.
复制标题
B型流感嗜血杆菌荚膜多糖疫苗接种后的血清抗体和对重新免疫的反应：没有免疫耐受或记忆的证据。
作者：
H. Käyhty;V. Karanko;Heikki Peltola;P. Mäkelä
1974年，芬兰为约5万名婴幼儿接种b型流感嗜血杆菌荚膜多糖疫苗，并对其血清抗H型流感衣壳多糖水平进行了3年半的跟踪调查。接种疫苗诱导的血清抗体在18个月以下的婴儿中存活时间很短(不到6个月)。在18~35个月接种疫苗的儿童中，血清抗体水平升高的时间持续了1年半，但不到3年半。在接种疫苗时3~5岁的儿童中，抗Hb型流感衣壳多糖水平升高至少持续了3年半。因此，在18个月大时接种疫苗的儿童可能需要在第一次接种后1到1年半的时间内再接种一剂疫苗，以便在高敏感期得到保护，直到大约7岁。部分儿童在第一次免疫后3年半再次免疫，用同样的方法检测其血清中抗H1b型流感衣壳多糖水平。在相同年龄的儿童中，再次免疫后的抗H型流感病毒b型衣壳多糖水平与第一次接种后的抗H型流感病毒b型衣壳多糖水平并无差异。
Haemophilus influenzae type b capsular polysaccharide vaccine was given in Finland in 1974 to approximately 50,000 infants and children, whose serum anti-H influenzae type b capsular polysaccharide levels have been followed for 3 1/2 years. The serum antibodies induced by the vaccination proved short-lived (less than 6 months) in the infants younger than 18 months. Elevated serum antibody levels were detectable for 1 1/2 years but less than 3 1/2 years in the children who were vaccinated when 18 to 35 months old. In the children who were 3 to 5 years old when vaccinated, the elevated anti-H influenzae type b capsular polysaccharide levels persisted for at least 3 1/2 years. Therefore, children vaccinated at the age of 18 months may need a new dose of vaccine 1 to 1 1/2 years after the first dose in order to be protected for the period of high susceptibility, until the age of approximately 7 years. Some of the vaccinated children were reimmunized 3 1/2 years after the first dose, and the anti-H influenzae type b capsular polysaccharide levels in their sera were studied in a similar manner. At no time did the anti-H influenzae type b capsular polysaccharide levels after the reimmunization differ from the anti-H influenzae type b capsular polysaccharide levels seen after the first vaccination in children of the same age.(ABSTRACT TRUNCATED AT 250 WORDS)