GENE AMPLIFICATIONS IN ADVANCED-STAGE HUMAN PROSTATE-CANCER
GENE AMPLIFICATIONS IN ADVANCED-STAGE HUMAN PROSTATE-CANCER
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DOI：
10.1007/bf00296872
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发表时间：
1995-01-01
影响因子：
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通讯作者：
LIDEREAU, R
中科院分区：
文献类型：
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作者：
FOURNIER, G;LATIL, A;LIDEREAU, R
基因扩增是在人类肿瘤中偶尔观察到的原癌基因改变的一种模式。在某些情况下，这种扩增可能具有预后价值(神经母细胞瘤中的N-myc，乳腺癌中的c-erbB2和int-2等)。原癌基因c-myc、c-erbB2和int-2在前列腺癌中的扩增还没有报道，前列腺癌和乳腺癌一样，是激素依赖性的。我们用Southern blotting方法在15例前列腺癌标本中扩增了这三种原癌基因，其中大多数是晚期前列腺癌(7例为C期，6例为D_1或D_2期)。我们证实，与乳腺癌病例相比，无论分期如何，c-myc和c-erbB2扩增均缺失。在6例D期肿瘤中，有1例伴有骨转移的晚期肿瘤可观察到INT-2扩增。INT-2扩增的确切频率及其在前列腺癌发生中的作用仍有待确定。
Gene amplification is a model of proto-oncogene alterations occasionally observed in human tumors. This amplification can, in some cases, have prognostic value (N-myc in neuroblastoma, c-erbB2 and int-2 in breast cancer, etc.). Amplifications of the proto-oncogenes c-myc, c-erbB2 and int-2 have not yet been report in prostate adenocarcinoma, which, like breast cancer, is hormone dependent. We sought amplifications of these three proto-oncogenes by means of Southern blotting in 15 human prostate adenocarcinoma specimens, most of which were advanced (7 stage C and 6 stage D1 or D2). We confirmed the lack of c-myc and c-erbB2 amplification, regardless of the stage, in contrast to the case of breast cancer. Int-2 amplification was observed in one advanced tumor with bone metastases, out of a total of six stage D tumors. The precise frequency of int-2 amplification and its role in prostate carcinogenesis remain to be determined.