Decisional regret in women receiving high risk or inconclusive prenatal cell-free DNA screening results.
Decisional regret in women receiving high risk or inconclusive prenatal cell-free DNA screening results.
复制标题
在接受高风险或不确定的产前无细胞DNA筛查结果的妇女中的决定性遗憾。
DOI：
10.1080/14767058.2018.1519541
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发表时间：
2020-04
影响因子：
1.8
通讯作者：
Allyse, Megan
中科院分区：
文献类型：
--
作者：
Gammon, Betsy L.;Jaramillo, Carolina;Riggan, Kirsten A.;Allyse, Megan
这项研究调查了接受高风险无细胞DNA（cfDNA）筛查结果的女性的经历，特别关注在接受高风险，虚假或不确定结果后的决策满意度。众所周知，无细胞DNA筛选在临床实践中迅速扩大。越来越多的女性接受cfDNA筛查，以筛查越来越广泛的染色体和微缺失综合征。然而，研究表明，归因于cfDNA筛查21三体的非常低的假阳性率并不适用于其他病症。作为对患者经历的更大研究的一部分，对40名正在或最近怀孕并从cfDNA筛查中获得高风险（n = 15），假阳性/阴性（n = 20）或不确定（n = 5）结果的女性进行了半结构化电话采访。三分之一的参与者不会选择在未来怀孕时进行cfDNA筛查，另外三分之一的参与者只会在特定情况下或小组范围有限的情况下进行筛查。许多女性报告说，在接受cfDNA筛查或收到结果之前，她们感到被收到的信息误导了。研究参与者描述了在提供cfDNA筛查时的临床对话问题;当结果返回时;以及关于假阳性存在的信息的可用性问题。这些报告表明，不充分的预测试讨论有助于妇女的经验，决策后收到高风险，假阳性，或不确定的结果感到遗憾。考虑到cfDNA筛查准确性的混乱，后续侵入性检测的流行，以及报告后悔选择cfDNA筛查的女性人数，应该重新评估提供cfDNA的模式。
This study examined the experiences of women receiving high-risk cell-free DNA (cfDNA) screening results, with particular focus on decisional satisfaction after receiving high-risk, false, or inconclusive results. It is already known that cell-free DNA screening is rapidly expanding in the clinical practice. A growing number of women are offered cfDNA screening for an increasingly broad range of chromosomal and microdeletion syndromes. However, research shows that the very low false positive rate attributed to cfDNA screening for trisomy 21 does not apply to other conditions. As a part of the larger study on patient experiences, 40 semistructured telephone interviews were conducted with women who were, or had recently been, pregnant and received high-risk (n = 15), false positive/negative (n = 20), or inconclusive (n = 5) results from cfDNA screening. One third of participants would not elect to have cfDNA screening in a future pregnancy, and another third would only have the screen under particular circumstances or if the scope of the panel was limited. Many women reported feeling misled by the information they received prior to accepting cfDNA screening or receiving their results. Study participants described issues with the clinical dialog when cfDNA screening is offered; when results are returned; and problems with the availability of information about the existence of false positives. These reports suggest that inadequate pretest discussion contributes to women’s experience of decisional regret after receiving high-risk, false positive, or inconclusive results. Given the confusion about cfDNA screening accuracy, the prevalence of follow-up invasive tests, and the number of women who reported that they regretted choosing cfDNA screening, the mode of offering cfDNA should be reassessed.
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影响因子：
9.8
作者：
Norton, Mary E.;Brar, Herb;Song, Ken
通讯作者：
Song, Ken
影响因子：
7.1
作者：
Ashoor, G.;Syngelaki, A.;Nicolaides, K. H.
通讯作者：
Nicolaides, K. H.
影响因子：
2.5
作者：
Shipp, TD;Shipp, DZ;Benacerraf, B
通讯作者：
Benacerraf, B
DOI：
10.3109/01674829309084441
发表时间：
1993-09-01
影响因子：
3.1
作者：
MARTEAU, TM;KIDD, J;SHAW, RW
通讯作者：
SHAW, RW
影响因子：
8.8
作者：
Gregg, Anthony R.;Skotko, Brian G.;Watson, Michael S.
通讯作者：
Watson, Michael S.