Testing cognitive function in elderly populations: the PROSPER study
Testing cognitive function in elderly populations: the PROSPER study
复制标题
DOI：
10.1136/jnnp.73.4.385
复制
发表时间：
2002-10-01
影响因子：
11
通讯作者：
Westendorp, RG
中科院分区：
文献类型：
--
作者：
Houx, PJ;Shepherd, J;Westendorp, RG
目的：对于以认知为终点的非痴呆患者的大规模随访研究，需要适合重复测量的简短、廉价、灵敏和可靠的神经心理学测试。常用的迷你精神状态检查满足只有前两个requires.Methods：在前瞻性研究普伐他汀在老年人的风险（PROSPER），5804老年人年龄在70至82岁进行了检查，使用学习测试（记忆），编码测试（一般速度），和一个简短的版本的Stroop测试（注意）。在这里提供的数据收集在双基线，随机化前积极treatment.Results：测试被证明是可靠的（与测试/重测可靠性范围从可接受的（r=0.63）到高（r=0.88）和敏感的检测小的差异，受试者从不同的年龄类别。所有的测试都表现出显着的实践效果：性能增加，从第一次测量到第一次随访后两weeks.Conclusion：规范的数据提供，可用于一次性神经心理测试，以及评估个人和团体的变化。提出了分析认知变化的方法。
Objectives: For large scale follow up studies with non-demented patients in which cognition is an end-point, there is a need for short, inexpensive, sensitive, and reliable neuropsychological tests that are suitable for repeated measurements. The commonly used Mini-Mental-State-Examination fulfils only the first two requirements.Methods: In the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), 5804 elderly subjects aged 70 to 82 years were examined using a learning test (memory), a coding test (general speed), and a short version of the Stroop test (attention). Data presented here were collected at dual baseline, before randomisation for active treatment.Results: The tests proved to be reliable (with test/retest reliabilities ranging from acceptable (r=0.63) to high (r=0.88) and sensitive to detect small differences in subjects from different age categories. All tests showed significant practice effects: performance increased from the first measurement to the first follow up after two weeks.Conclusion: Normative data are provided that can be used for one time neuropsychological testing as well as for assessing individual and group change. Methods for analysing cognitive change are proposed.