Perspectives on ENCODE
Perspectives on ENCODE
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DOI：
10.1038/s41586-020-2449-8
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发表时间：
2020-07-30
期刊：
影响因子：
64.8
通讯作者：
Myers, Richard M.
中科院分区：
文献类型：
--
作者：
Snyder, Michael P.;Gingeras, Thomas R.;Myers, Richard M.
2003年启动的DNA元件百科全书（ENCODE）项目的长期目标是开发人类基因组功能元件的综合图谱。这些包括基因、与基因调控相关的生物化学区域（例如，转录因子结合位点、开放染色质和组蛋白标记）和转录本亚型。这些标记作为cCREs的位点，cCREs可能在调节基因表达中发挥功能作用（1）。该项目已扩展到模型生物，特别是小鼠。在ENCODE的第三阶段，已经分别为人类和小鼠生成了近100万条和30多万条cCRE注释，这些注释为科学界提供了宝贵的资源。作者总结了ENCODE项目的历史，ENCODE 1和ENCODE 2的成就，以及ENCODE 3中生成和分析的新数据如何补充以前的阶段。
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidatecis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression(1). The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.