The Relationship Between Symptom Prevalence and Severity and Cancer Primary Site in 796 Patients With Advanced Cancer
The Relationship Between Symptom Prevalence and Severity and Cancer Primary Site in 796 Patients With Advanced Cancer
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DOI：
10.1177/1049909110391464
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发表时间：
2011-08-01
影响因子：
1.9
通讯作者：
Karafa, Matthew T.
中科院分区：
文献类型：
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作者：
Kirkova, Jordanka;Rybicki, Lisa;Karafa, Matthew T.
了解癌症部位之间症状体验的差异可能有助于更好地理解症状病理生理学。对796例连续晚期癌症患者的38种症状进行了回顾性分析。通过卡方检验比较12个主要部位组（PSG）的症状患病率和严重程度。两两比较确定了哪些位点不同。疼痛、疲劳、虚弱、缺乏能量和厌食症的总体患病率最高，但在PSG中没有差异。3种最常见的神经心理症状（失眠、抑郁和焦虑）在PSG中也没有变化。19例（50%）症状在PSG之间的患病率（17例）、严重程度（14例）或两者（12例）方面存在显著差异。17例中有9例、14例中有6例和12例中有6例为胃肠道症状。不同PSG的症状可以包含在癌症部位特定症状评估工具中。
Knowledge of differences in symptom experience between cancer sites may help better understand symptom pathophysiology. A total of 38 symptoms in 796 consecutive patients with advanced cancer were retrospectively analyzed. Symptom prevalence and severity were compared among the 12 primary site groups (PSGs) by the chi-square test. Pairwise comparisons determined which sites differed. Pain, fatigue, weakness, lack of energy, and anorexia had the highest overall prevalence but did not differ among PSGs. The 3 most common neuropsychological symptoms (insomnia, depression, and anxiety) also did not vary among PSGs. Nineteen (50%) symptoms varied significantly between PSGs, in prevalence (17), severity (14), or both (12). Nine of 17, 6 of 14, and 6 of 12 were gastrointestinal symptoms. Symptoms which varied by PSGs can be included in cancer site-specific symptom assessment instruments.