Possible involvement of corticosterone and serotonin in antidepressant and antianxiety effects of chromium picolinate in chronic unpredictable mild stress induced depression and anxiety in rats
Possible involvement of corticosterone and serotonin in antidepressant and antianxiety effects of chromium picolinate in chronic unpredictable mild stress induced depression and anxiety in rats
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DOI：
10.1016/j.jtemb.2014.06.014
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发表时间：
2015-01-01
影响因子：
3.5
通讯作者：
Khanam, Razia
中科院分区：
文献类型：
--
作者：
Dubey, Vivek Kumar;Ansari, Faraha;Khanam, Razia
在本研究中，我们研究了吡啶甲酸铬（CrP）对慢性不可预见的轻度应激（CNOMS）诱导的抑郁和焦虑大鼠的行为和生化指标的影响。对正常和应激的雄性瑞士白化病大鼠给予磷酸肌酸（8和16 μ g/mL的饮用水），它们接受7天的应激（每天一种应激），并重复该循环3次，持续21天。在第22天，进行行为评估，然后进行生化评估。结果表明，慢性不可预见性轻度应激（CHR）所致抑郁大鼠在改良强迫游泳试验（FST）中不动时间明显缩短，表明磷酸肌酸具有明显的抗抑郁作用。在高架十字迷宫中，16 μ g/mL的CrP能显著减少大鼠在开放臂中的时间，8 μ g/mL和16 μ g/mL的CrP能显著减少大鼠进入开放臂的次数，表明CrP对大鼠的抗焦虑作用。还发现，磷酸肌酸（8和16微克/毫升）显着增加5-羟色胺浓度的离散区域的大脑（皮层和小脑）。另一方面，血浆皮质酮水平显著降低与磷酸肌酸（16 μ g/mL）。结果提示，5-HT浓度升高和血浆皮质酮水平降低可能是改善抑郁和焦虑症状的原因。(C)2014 Elsevier GmbH. All rights reserved.
In the present study, we investigated the effects of chromium picolinate (CrP) on behavioural and biochemical parameters in chronic unpredictable mild stress (CUMS) induced depression and anxiety in rats. The normal and stressed male Swiss albino rats were administered CrP (8 and 16 mu g/mL in drinking water), they received stressors for seven days (each day one stressor) and this cycle was repeated three times for 21 days. On 22nd day, behaviour assessments followed by biochemical estimations were conducted. The results showed that treatment of CrP produced significant antidepressant effect, which has been evidenced by decrease in immobility time in modified forced swimming test (FST) in chronic unpredictable mild stress (CUMS) induced depression in rats. In elevated plus maze (EPM), CrP (16 mu g/mL) showed significant reduction in time spent in open arm. CrP (8 mu g/mL and 16 mu g/mL) also showed significant decrease in number of entries in open arm that shows antianxiety effect of CrP in CUMS rats. It was also found that CrP (8 and 16 mu g/mL) significantly increased 5-HT concentration in the discrete regions of brain (cortex and cerebellum). On the other hand, the plasma corticosterone level was significantly decreased with CrP (16 mu g/mL). The results suggested that increase in the concentration of 5-HT and decrease in plasma corticosterone levels could be responsible for improvement in symptoms of depression and anxiety in CUMS induced depression and anxiety in rats. (C) 2014 Elsevier GmbH. All rights reserved.