A Compendium of the Mouse Mammary Tumor Biologist: From the Initial Observations in the House Mouse to the Development of Genetically Engineered Mice
A Compendium of the Mouse Mammary Tumor Biologist: From the Initial Observations in the House Mouse to the Development of Genetically Engineered Mice
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DOI：
10.1101/cshperspect.a003111
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发表时间：
2011-06-01
影响因子：
7.2
通讯作者：
Kenney, Nicholas
中科院分区：
文献类型：
--
作者：
Cardiff, Robert D.;Kenney, Nicholas
世纪以来，小鼠乳腺肿瘤生物学和相关的小鼠乳腺肿瘤病毒（MMTV）一直是实验性癌症研究的基础，特别是实验性乳腺癌研究。自发性小鼠乳腺肿瘤是研究肿瘤形成自然史、致癌病毒、宿主反应、内分泌学和肿瘤进展的基础。然而，由于缺乏人类乳腺肿瘤病毒的正式证据，小鼠模型的优势在20世纪80年代逐渐消失。自20世纪80年代末以来，基因工程小鼠（GEM）已被证明对研究乳腺癌非常有用，并已成为人类乳腺癌的动物模型。自1984年首次展示以来，已经开发了数百种人类乳腺癌小鼠模型。GEM吸引了新一代的分子和细胞生物学家，他们渴望将自己的技能应用于这些人类疾病的替代品。新手进入该领域时，往往不了解小鼠乳腺肿瘤生物学的起源和许多流行概念的基础。我们写这本纲要的目的是伸出“橄榄分支”，同时加深新手小鼠乳腺肿瘤生物学家的知识，因为他们进入了一个跨越几个世纪的病理学和遗传学丰富的领域。
For over a century, mouse mammary tumor biology and the associated mouse mammary tumor virus (MMTV) have served as the foundation for experimental cancer research, in general, and, in particular, experimental breast cancer research. Spontaneous mouse mammary tumors were the basis for studies of the natural history of neoplasia, oncogenic viruses, host responses, endocrinology and neoplastic progression. However, lacking formal proof of a human mammary tumor virus, the preeminence of the mouse model faded in the 1980s. Since the late 1980s, genetically engineered mice (GEM) have proven extremely useful for studying breast cancer and have become the animal model for human breast cancer. Hundreds of mouse models of human breast cancer have been developed since the first demonstration in 1984. The GEM have attracted a newgeneration of molecular and cellular biologists eager to apply their skill sets to these surrogates of the human disease. Newcomers often enter the field without an appreciation of the origins of mouse mammary tumor biology and the basis for many of the prevailing concepts. Our purpose in writing this compendium is to extend an "olive branch" while simultaneously deepen the knowledge of the novice mouse mammary tumor biologist as they journey into a field rich in pathology and genetics spanning several centuries.